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Found 310 with Last Name = 'mack' and Initial = 'jf'
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169013(CHEMBL3805703)
Affinity DataKi:  2.90E+3nMAssay Description:Competitive inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) assessed as formation of G6P by continuou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420316(CHEMBL2089119)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420311(CHEMBL2089114)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420321(CHEMBL2089112)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420309(CHEMBL2089120)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420317(CHEMBL2089118)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420310(CHEMBL2089116)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420312(CHEMBL2089109)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420313(CHEMBL2089108)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420314(CHEMBL2089107)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365868(CHEMBL1957857)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365882(CHEMBL1957870)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420311(CHEMBL2089114)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420316(CHEMBL2089119)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365867(CHEMBL1957856)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365869(CHEMBL1957858)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420309(CHEMBL2089120)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365865(CHEMBL1957841)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420321(CHEMBL2089112)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365866(CHEMBL1957855)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420324(CHEMBL2089105)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420325(CHEMBL2089104)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420322(CHEMBL2089111)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420320(CHEMBL2089113)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365882(CHEMBL1957870)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kdelta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365873(CHEMBL1957862)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420318(CHEMBL2089117)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365880(CHEMBL1957868)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365890(CHEMBL1957875)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365872(CHEMBL1957861)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169033(CHEMBL3806069)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169038(CHEMBL3804841)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169042(CHEMBL3806103)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420319(CHEMBL2089115)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365870(CHEMBL1957859)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365868(CHEMBL1957857)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kdelta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420314(CHEMBL2089107)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420310(CHEMBL2089116)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420317(CHEMBL2089118)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169037(CHEMBL3805205)
Affinity DataIC50:  10nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420326(CHEMBL2089103)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365884(CHEMBL1957872)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365880(CHEMBL1957868)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kdelta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420313(CHEMBL2089108)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365864(CHEMBL1957840)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365871(CHEMBL1957860)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365878(CHEMBL1957866)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365878(CHEMBL1957866)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365878(CHEMBL1957866)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kdelta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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