Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 10.5nMAssay Description:Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Sungkyunkwan University
Curated by ChEMBL
Sungkyunkwan University
Curated by ChEMBL
Affinity DataIC50: 11.1nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 expressed i...More data for this Ligand-Target Pair
Affinity DataIC50: 11.4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) expressed in insect cells/baculovirus expression system using RHK-K(...More data for this Ligand-Target Pair
Affinity DataIC50: 23.2nMAssay Description:Inhibition of human recombinant HDAC9 using trifluoroacetyl lysine as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human HDAC6 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34.8nMAssay Description:Inhibition of human recombinant HDAC10 using RHK-K(Ac)-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 40.9nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 108nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using Boc-K(TFA)-A...More data for this Ligand-Target Pair
Affinity DataIC50: 199nMAssay Description:Inhibition of recombinant human HDAC6 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 307nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-K(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of HDAC in human HeLa cells using Boc-acetyl-lysine-AMC as substrate incubated for 24 hrs by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 567nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-K(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Sungkyunkwan University
Curated by ChEMBL
Sungkyunkwan University
Curated by ChEMBL
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 expressed i...More data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using Boc-K(TFA)-A...More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.28E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) expressed in insect cells/baculovirus expression system using RHK-K(...More data for this Ligand-Target Pair
Affinity DataIC50: 7.83E+4nMAssay Description:Inhibition of human recombinant HDAC10 using RHK-K(Ac)-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 750nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair