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Found 324 with Last Name = 'magnaghi' and Initial = 'p'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of recombinant ALK (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TRKA (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170106(CHEMBL3805643)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKA (440 to 796 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKB (455 to 822 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human TRKB incubated for 90 mins by selectscreen kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKC (454 to 825 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TEL (336 residues) fused-ROS1 (1891 to 2347 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human TRKC incubated for 90 mins by selectscreen kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROS1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170108(CHEMBL3806122)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170102(CHEMBL3805123)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170100(CHEMBL3805899)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170105(CHEMBL3805741)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170104(CHEMBL3805020)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170107(CHEMBL3806112)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170077(CHEMBL3805214)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424917(CHEMBL2311578)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424919(CHEMBL2315422)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170112(CHEMBL3805749)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040551(CHEMBL3361184)
Affinity DataIC50:  27nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170106(CHEMBL3805643)
Affinity DataIC50:  28nMAssay Description:Inhibition of IGF1R (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170079(CHEMBL3805002)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040550(CHEMBL3361185)
Affinity DataIC50:  36nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170080(CHEMBL3805462)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  40nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170106(CHEMBL3805643)
Affinity DataIC50:  41nMAssay Description:Inhibition of IR (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424939(CHEMBL2315430)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424938(CHEMBL2315431)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424942(CHEMBL2315427)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040513(CHEMBL3361210)
Affinity DataIC50:  46nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424941(CHEMBL2315428)
Affinity DataIC50:  48nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424916(CHEMBL2315424)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424918(CHEMBL2315423)
Affinity DataIC50:  54nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424920(CHEMBL2315421)
Affinity DataIC50:  58nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170076(CHEMBL3804988)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040506(CHEMBL3361216)
Affinity DataIC50:  59nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040557(CHEMBL3361178)
Affinity DataIC50:  60nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040499(CHEMBL3361223)
Affinity DataIC50:  61nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424937(CHEMBL2315432)
Affinity DataIC50:  63nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424936(CHEMBL2315433)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424915(CHEMBL2315425)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170101(CHEMBL3806280)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50170081(CHEMBL3805516)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  70nMAssay Description:Inhibition of ACK1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424884(CHEMBL2315450)
Affinity DataIC50:  71nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424921(CHEMBL2315420)
Affinity DataIC50:  71nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040498(CHEMBL3361224)
Affinity DataIC50:  71nMAssay Description:Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50424940(CHEMBL2315429)
Affinity DataIC50:  71nMAssay Description:Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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