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Found 144 with Last Name = 'makita' and Initial = 'n'
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260712((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-iso...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377918(CHEMBL1162994)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260627((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2-...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260672((S)-N-(1-cyano-2,2-dimethylpropyl)-3-(2-morpholino...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260673((S)-N-(2,2-dimethyl-1-(2-methyl-2H-tetrazol-5-yl)p...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260709(CHEMBL496497 | N-((S)-1-amino-3,3-dimethyl-1-oxobu...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261052((R)-3-(2-morpholinoethyl)-2-oxo-N-(1,2,3,4-tetrahy...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261051(3-(2-morpholinoethyl)-N-(naphthalen-1-yl)-2-oxo-2,...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260753((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(3-...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261099((R)-1-(2-morpholinoethyl)-2-oxo-N-(1,2,3,4-tetrahy...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260674((S)-N-(2,2-dimethyl-1-(3-methyl-1,2,4-oxadiazol-5-...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260514((S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-(2-morp...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260626((S)-N'-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260538((S)-N-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261053(1-(2-morpholinoethyl)-N-(naphthalen-1-yl)-2-oxo-1,...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260512(CHEMBL494563 | N-(2-hydroxy-1,2,3,4-tetrahydronaph...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261100(CHEMBL494627 | N-cyclohexyl-3-(2-morpholinoethyl)-...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260628(CHEMBL495391 | N-((2S,3S)-1-amino-3-methyl-1-oxope...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260712((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-iso...)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260511(CHEMBL495407 | N-(chroman-4-yl)-3-(2-morpholinoeth...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260750((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-((4...)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260751((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2-...)
Affinity DataKi:  144nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260752((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2-...)
Affinity DataKi:  196nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261102(CHEMBL493804 | N-(1-(4-fluorophenyl)ethyl)-3-(2-mo...)
Affinity DataKi:  232nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260710((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-2-oxo...)
Affinity DataKi:  242nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260711((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(2-...)
Affinity DataKi:  338nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260513(CHEMBL494564 | N-((1S,2S)-2-hydroxycyclohexyl)-3-(...)
Affinity DataKi:  484nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260709(CHEMBL496497 | N-((S)-1-amino-3,3-dimethyl-1-oxobu...)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260753((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-(3-...)
Affinity DataKi:  1.46E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377918(CHEMBL1162994)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260673((S)-N-(2,2-dimethyl-1-(2-methyl-2H-tetrazol-5-yl)p...)
Affinity DataKi:  1.48E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261099((R)-1-(2-morpholinoethyl)-2-oxo-N-(1,2,3,4-tetrahy...)
Affinity DataKi:  1.51E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261052((R)-3-(2-morpholinoethyl)-2-oxo-N-(1,2,3,4-tetrahy...)
Affinity DataKi:  1.73E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260511(CHEMBL495407 | N-(chroman-4-yl)-3-(2-morpholinoeth...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260626((S)-N'-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataKi:  2.72E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260750((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-((4...)
Affinity DataKi:  3.01E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50260628(CHEMBL495391 | N-((2S,3S)-1-amino-3-methyl-1-oxope...)
Affinity DataKi: >4.04E+3nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231044(CHEMBL252011 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231058(CHEMBL438345 | N-((6-hydroxy-9-methyl-2,3,4,9-tetr...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231044(CHEMBL252011 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)
Affinity DataIC50:  44nMAssay Description:Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231043(CHEMBL400086 | N-(4-tert-butylphenyl)-4-(1,1,2,2-t...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231088(CHEMBL253624 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)
Affinity DataIC50:  76nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231110(CHEMBL400779 | N-(1-(7-hydroxynaphthalen-1-yl)prop...)
Affinity DataIC50:  81nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231051(CHEMBL252226 | N-(4-tert-butylphenyl)-4-(trifluoro...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231076(CHEMBL253623 | N-(2-(7-hydroxynaphthalen-1-yl)ethy...)
Affinity DataIC50:  150nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231082(CHEMBL252989 | N-((6-hydroxy-2,3,4,9-tetrahydro-1H...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231109(CHEMBL254899 | N-(2,6-dichlorophenethyl)-4-(triflu...)
Affinity DataIC50:  205nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231098(CHEMBL253840 | N-(2,3-dihydro-1H-inden-5-yl)-4-(tr...)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231068(CHEMBL252782 | N-(4-tert-butylphenyl)-4-(trifluoro...)
Affinity DataIC50:  220nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231048(4-(trifluoromethoxy)-N-(4-(trifluoromethyl)phenyl)...)
Affinity DataIC50:  220nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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