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Found 212 with Last Name = 'marsters' and Initial = 'jc'
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179795(CHEMBL382690 | PVKRRL-(3-Cl)F-NH2)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119092(4-Methyl-piperazine-1-carboxylic acid 4-[(S)-2-car...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50108219((5S,8R,13R)-8-[(S)-2-Acetylamino-3-(4-hydroxy-phen...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284631(2-(2-{3-[(2-Amino-3-mercapto-propionyl)-methyl-ami...)
Affinity DataIC50:  2.10nMAssay Description:Tested for inhibitory activity against rat brain p21ras Ras Farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179784(CHEMBL381053 | N-((S)-1-((S)-1-(trans-2-(3-chlorop...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302111(CHEMBL572255 | N-(4-chloro-3-(1-methyl-1H-benzo[d]...)
Affinity DataIC50:  9nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119089((S)-2-(2-Chloro-benzoylamino)-3-(4-dimethylcarbamo...)
Affinity DataIC50:  9.30nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179803(CHEMBL440581 | PVKRRLFA)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179797(CHEMBL206400 | PAKRRLFG)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119096((S)-2-(2-Chloro-benzoylamino)-3-[2'-(4-methyl-pipe...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50108219((5S,8R,13R)-8-[(S)-2-Acetylamino-3-(4-hydroxy-phen...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119093((S)-2-(2-Chloro-benzoylamino)-3-(2'-dimethylaminom...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119092(4-Methyl-piperazine-1-carboxylic acid 4-[(S)-2-car...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302139(CHEMBL570273 | N-(3-(1H-benzo[d]imidazol-2-yl)-4-c...)
Affinity DataIC50:  12nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179798(CHEMBL206617 | PVKRRLFG)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179789(CHEMBL381309 | PVKRRLF)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179801(AVKRRLFG | CHEMBL381957)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119093((S)-2-(2-Chloro-benzoylamino)-3-(2'-dimethylaminom...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119083((S)-2-(2-Chloro-benzoylamino)-3-(4-phenethylcarbam...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119085((S)-2-(2-Chloro-benzoylamino)-3-(4-propylcarbamoyl...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179814(CHEMBL205076 | N-((S)-1-((S)-1-(trans-2-(3-chlorop...)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119089((S)-2-(2-Chloro-benzoylamino)-3-(4-dimethylcarbamo...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119096((S)-2-(2-Chloro-benzoylamino)-3-[2'-(4-methyl-pipe...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119087((S)-2-(2-Chloro-benzoylamino)-3-(2'-{[2-(4-hydroxy...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119087((S)-2-(2-Chloro-benzoylamino)-3-(2'-{[2-(4-hydroxy...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179782(CHEMBL382815 | PVKRRLF-NH2)
Affinity DataIC50:  28nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179806(CHEMBL379697 | N-((S)-1-((S)-1-(trans-2-(3-chlorop...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119097((S)-3-(4-Allylcarbamoyloxy-phenyl)-2-(2-chloro-ben...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179802(CHEMBL203101 | trans-N-((S)-4-methyl-1-oxo-1-(tran...)
Affinity DataIC50:  40nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302138(CHEMBL570712 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  40nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119085((S)-2-(2-Chloro-benzoylamino)-3-(4-propylcarbamoyl...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302123(CHEMBL571353 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  42nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179787(CHEMBL206396 | N-((S)-1-((S)-1-(trans-2-(3-chlorop...)
Affinity DataIC50:  47nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119088((S)-2-(2-Chloro-benzoylamino)-3-(3'-{[2-(4-hydroxy...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119090((S)-2-(2-Chloro-benzoylamino)-3-[2'-(phenethylamin...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119095((S)-2-(2-Chloro-benzoylamino)-3-{2'-[(3-methyl-but...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119094((S)-2-(2-Chloro-benzoylamino)-3-(2'-methoxy-biphen...)
Affinity DataIC50:  51nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302128(CHEMBL570936 | N-(4-chloro-3-(quinoxalin-2-yl)phen...)
Affinity DataIC50:  52nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119088((S)-2-(2-Chloro-benzoylamino)-3-(3'-{[2-(4-hydroxy...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119097((S)-3-(4-Allylcarbamoyloxy-phenyl)-2-(2-chloro-ben...)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179812(CHEMBL205197 | N-((S)-1-((S)-1-(trans-2-(3-chlorop...)
Affinity DataIC50:  58nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119090((S)-2-(2-Chloro-benzoylamino)-3-[2'-(phenethylamin...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179790(CHEMBL381396 | PVARRLFG)
Affinity DataIC50:  62nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302113(CHEMBL572005 | N-(3-(benzo[d]thiazol-2-yl)-4-chlor...)
Affinity DataIC50:  70nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119091((S)-2-(2-Chloro-benzoylamino)-3-(4-p-tolylcarbamoy...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosal addressin cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284630((R)-2-(2-{(S)-3-[((R)-2-Amino-3-mercapto-propionyl...)
Affinity DataIC50:  80nMAssay Description:Tested for inhibitory activity against rat brain p21ras Ras Farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302115(CHEMBL569818 | N-(4-chloro-3-(2H-indazol-2-yl)phen...)
Affinity DataIC50:  80nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50119095((S)-2-(2-Chloro-benzoylamino)-3-{2'-[(3-methyl-but...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against alpha4-beta1 integrin (vascular cell adhesion molecule) in ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50144081((S)-2-(2-Chloro-6-fluoro-benzoylamino)-succinamic ...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against association of LFA-1 with intercellular adhesion molecule 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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