TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 4.30nM ΔG°: -47.3kJ/mole EC50: 14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 5.10nM ΔG°: -46.9kJ/mole EC50: 8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 10nM ΔG°: -45.2kJ/mole EC50: 15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 14nM ΔG°: -44.4kJ/mole EC50: 23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 15nM ΔG°: -44.2kJ/mole EC50: 19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 33nM ΔG°: -42.3kJ/mole EC50: 41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 48nM ΔG°: -41.4kJ/mole EC50: 81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 50nM ΔG°: -41.3kJ/mole EC50: 130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 70nM ΔG°: -40.4kJ/mole EC50: 250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 94nM ΔG°: -39.7kJ/mole EC50: 220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 180nM ΔG°: -38.1kJ/mole EC50: 150nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 200nM ΔG°: -37.9kJ/mole EC50: 270nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 220nM ΔG°: -37.6kJ/mole EC50: 750nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 480nM ΔG°: -35.7kJ/mole EC50: 1.70E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 840nM ΔG°: -34.3kJ/mole EC50: 600nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
Astrazeneca
Astrazeneca
Affinity DataKi: 2.10E+3nM ΔG°: -32.1kJ/mole EC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was tested for in vitro inhibition of osteoclast vacuolar acid pumpMore data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair