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Found 84 with Last Name = 'mattsson' and Initial = 'jp'
LigandPNGBDBM24198(3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole EC50:  14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24195(3-aminopropylphosphinic derivative, (R)-7 | AZD335...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole EC50:  8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24193((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24196((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole EC50:  23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | 3-aminopropylphos...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/mole EC50:  19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
LigandPNGBDBM24191((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/mole EC50:  130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24194(3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/mole EC50:  250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/mole EC50:  220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  180nM ΔG°:  -38.1kJ/mole EC50:  150nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24192((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...)
Affinity DataKi:  200nM ΔG°:  -37.9kJ/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...)
Affinity DataKi:  220nM ΔG°:  -37.6kJ/mole EC50:  750nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
LigandPNGBDBM24197(3-aminopropylphosphinic derivative, (S)-8 | [(2S)-...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole EC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  840nM ΔG°:  -34.3kJ/mole EC50:  600nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  2.10E+3nM ΔG°:  -32.1kJ/mole EC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVacuolar proton pump subunit B(Gallus gallus)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50064186((3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-...)
Affinity DataIC50:  30nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVacuolar proton pump subunit B(Gallus gallus)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50064182((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...)
Affinity DataIC50:  49nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182823(4-(3,4-dichlorophenylthio)-2-(5-fluoropyridin-2-yl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182811(4-(3,4-dichlorophenylthio)-2-(pyridin-2-yl)pyrimid...)
Affinity DataIC50:  90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182813(2-(pyridin-2-yl)-4-(4-(trifluoromethyl)phenylthio)...)
Affinity DataIC50:  210nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50:  260nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50:  320nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182822(4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine ...)
Affinity DataIC50:  320nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM86716(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)
Affinity DataIC50:  330nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179667(1-(3-bromophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  380nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182819(4-(3,4-dichlorophenylthio)-2-(6-methylpyridin-2-yl...)
Affinity DataIC50:  390nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50:  410nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM86716(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)
Affinity DataIC50:  460nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50:  490nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182816(2-(pyridin-2-yl)-4-(3-(trifluoromethyl)phenylthio)...)
Affinity DataIC50:  550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179669(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-m-tolyl...)
Affinity DataIC50:  550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182809(4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine ...)
Affinity DataIC50:  620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50:  620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50:  680nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50:  800nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182814(4-(4-chlorophenylthio)-6-methyl-2-(pyridin-2-yl)py...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179644(1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVacuolar proton pump subunit B(Gallus gallus)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50086850((2E,4E)-Hexa-2,4-dienedioic acid (3,4-dichloro-phe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Compound was tested for in vitro inhibition of osteoclast vacuolar acid pumpMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182821(4-(3,4-difluorophenylthio)-2-(pyridin-2-yl)pyrimid...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50:  1.60E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182815(2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine | CHEMB...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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