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Found 137 with Last Name = 'miyoshi' and Initial = 'h'
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-JNJ962 from BACE1 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-JNJ962 from BACE2 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]-imipramine from recombinant human 5-HT transporter after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  7.20E+3nMAssay Description:Displacement of [3H]-pirenzepine from human recombinant muscarinic 1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  7.40E+3nMAssay Description:Displacement of [3H]-CCPA from human recombinant adenosine A1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  8.20E+3nMAssay Description:Displacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50512479(CHEMBL4456440)
Affinity DataIC50:  0.0610nMAssay Description:Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579804(CHEMBL5093088)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50116000((S)-3-{(12R,13R)-13-Hydroxy-13-[(4R,2'R,5'R)-5'-((...)
Affinity DataIC50:  0.75nMAssay Description:Inhibitory concentration needed to halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11(Bos taurus)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50116000((S)-3-{(12R,13R)-13-Hydroxy-13-[(4R,2'R,5'R)-5'-((...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity of the compound against bovine heart mitochondrial NADH ubiquinone oxidoreductase (complex I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366820(BULLATACIN)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of complex I activity was determined by NADH oxidase assay using bovine heart submitochondrial particles.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50116000((S)-3-{(12R,13R)-13-Hydroxy-13-[(4R,2'R,5'R)-5'-((...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of complex I activity was determined by NADH oxidase assay using bovine heart submitochondrial particles.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579805(CHEMBL5075689)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92960(Piperazine derivative, 24)
Affinity DataIC50:  1nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92945(Piperazine derivative, 10)
Affinity DataIC50:  1.20nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130144(2-{(12R,13R)-13-Hydroxy-13-[(4R,2'R,5'R)-5'-((R)-1...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of complex I activity was determined by NADH oxidase assay using bovine heart submitochondrial particles.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579813(CHEMBL5091877)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579813(CHEMBL5091877)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcyl carrier protein, mitochondrial(Bos taurus)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50411085(CHEMBL464549)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase by NADH oxidase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92949(Piperazine derivative, 13)
Affinity DataIC50:  1.70nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92946(Piperazine derivative, 9)
Affinity DataIC50:  1.70nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579808(CHEMBL5081571)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM50427137(SOLAMIN)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of bovine heart mitochondrial complex 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92955(Piperazine derivative, 19)
Affinity DataIC50:  2.20nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579810(CHEMBL5074678)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92948(Piperazine derivative, 12)
Affinity DataIC50:  2.30nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579808(CHEMBL5081571)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579811(CHEMBL5084928)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92941(Piperazine derivative, 5)
Affinity DataIC50:  2.60nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
LigandPNGBDBM50139593((S)-3-{13-[(2R,5S,1'R,3'R)-5'-((R)-1-Hydroxy-undec...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration needed to halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92950(Piperazine derivative, 14)
Affinity DataIC50:  2.80nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579810(CHEMBL5074678)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM50427136(CHEMBL1834283)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of bovine heart mitochondrial complex 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579810(CHEMBL5074678)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM50411905(CHEMBL272733)
Affinity DataIC50:  3nMAssay Description:Inhibition of Bos taurus (bovine) mitochondrial complex 1 assessed as reduction in enzyme activity by NADH-HU oxidoreductase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579807(CHEMBL5074719)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50139595((S)-3-[(R)-13-Hydroxy-13-((2R,5R,1'S,3'R)-5'-undec...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory concentration needed to halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11(Bos taurus)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50115999((S)-3-{(R)-13-Hydroxy-13-[(2R,5R,2'R,5'R)-5'-((R)-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity of the compound against bovine heart mitochondrial NADH ubiquinone oxidoreductase (complex I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579807(CHEMBL5074719)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate incubated for 2 hrs by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcyl carrier protein, mitochondrial(Bos taurus)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50411084(CHEMBL208839)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase by NADH oxidase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579807(CHEMBL5074719)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92956(Piperazine derivative, 20)
Affinity DataIC50:  3.60nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50501808(CHEMBL4465534)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579814(CHEMBL5090362)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579810(CHEMBL5074678)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
TargetNADH-ubiquinone oxidoreductase chain 1(Bos taurus (Bovine))
Kyoto University

LigandPNGBDBM92947(Piperazine derivative, 11)
Affinity DataIC50:  5.90nMAssay Description:Inhibition assay using NADH-ubiquinone oxidoreductase (complex I).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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