TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 119nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 817nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 3.00E+3nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 4.62E+3nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at wild type rat NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced curren...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Antagonist activity at rat recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 113nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 173nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 177nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 188nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 207nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 238nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 253nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 275nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 278nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 281nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 357nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 397nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 409nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 421nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 427nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 429nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 433nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 479nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Binding affinity to dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Binding affinity to norepinephrine transporterMore data for this Ligand-Target Pair