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Found 24 with Last Name = 'narula' and Initial = 'g'
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50:  970nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514842(CHEMBL4566791)
Affinity DataIC50: <3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in absence of cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514842(CHEMBL4566791)
Affinity DataIC50: <3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259213(CHEMBL4079855 | US10266550, Compound 7e)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027668(CHEMBL3357531)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027673(Olympicin A)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027665((E)-1-(2,4-dihydroxyphenyl)-3-(2-allyloxyphenyl)-2...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027671(CHEMBL3357510)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027670(CHEMBL3357527)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027669(CHEMBL3357528)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027667(CHEMBL3357537)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027666(CHEMBL3357535)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027672(CHEMBL3357489)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed