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Found 281 with Last Name = 'newcombe' and Initial = 'nj'
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047420(CHEMBL3319405)
Affinity DataKi:  52nMAssay Description:Inhibition of alpha4 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047420(CHEMBL3319405)
Affinity DataKi:  290nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047485(CHEMBL3319217)
Affinity DataIC50:  0.0780nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047481(CHEMBL3319221)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047429(CHEMBL3319398)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047480(CHEMBL3319222)
Affinity DataIC50:  0.290nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047482(CHEMBL3319220)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047431(CHEMBL3319397)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047483(CHEMBL3319219)
Affinity DataIC50:  0.330nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047688(CHEMBL3319407)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047426(CHEMBL3319400)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047474(CHEMBL3319228)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Rattus norvegicus (rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of rat DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of DGAT1-mediated triacylglycerol synthesis in human HuTu80 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047475(CHEMBL3319227)
Affinity DataIC50:  0.530nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047428(CHEMBL3319399)
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047432(CHEMBL3319396)
Affinity DataIC50:  0.620nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047478(CHEMBL3319225)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047479(CHEMBL3319224)
Affinity DataIC50:  0.690nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047418(CHEMBL3319223)
Affinity DataIC50:  0.770nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047687(CHEMBL3319406)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50263028(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047434(CHEMBL3319229)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047416(CHEMBL3319215)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50:  2nMAssay Description:Inhibition of 11betaHSD1 in human isolated adipocytes using [3H]cortisone as substrate after 6 hrs by flow scintillation analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7657(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047423(CHEMBL3319402)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025068(CHEMBL484555)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025069(CHEMBL485425)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243148(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(thiophen-2-y...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243624((R)-1-(3-(azepan-3-ylcarbamoyl)-5-phenylthiophen-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047418(CHEMBL3319223)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/3/4/6/7(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047416(CHEMBL3319215)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047424(CHEMBL3319401)
Affinity DataIC50:  3.90nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274698(4-(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)pyrimidin-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243151((S)-1-(3-(piperidin-3-ylcarbamoyl)-5-(pyridin-4-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047490(CHEMBL3319216)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385439(CHEMBL2036745)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243201((S)-1-(5-(4-carbamoylphenyl)-3-(piperidin-3-ylcarb...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243047(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-carbamoylp...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047484(CHEMBL3319218)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385429(CHEMBL2036734)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243149(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(thiophen-3-y...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243102((S)-1-(5-(4-(methylsulfonyl)phenyl)-3-(piperidin-3...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274662(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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