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Found 175 with Last Name = 'nirschl' and Initial = 'a'
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29321(oxazolidin-2-imine, 6d)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/mole EC50:  19nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50215709(CHEMBL1170 | Propionic acid (8R,9S,10R,13S,14S,17S...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29319(oxazolidin-2-imine, 6b)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  14nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29323(oxazolidin-2-imine, 6f)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  1.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29320(BMS-665139 | oxazolidin-2-imine, 6c)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  0.200nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50215713(2-Chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrah...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18188(4-[(1S,7aR)-1-hydroxy-7-methyl-5-oxo-2,3,5,7a-tetr...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/mole EC50:  2nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29324(oxazolidin-2-imine, 6g)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/mole EC50:  3.70nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18183(4-[(1S,7R,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/mole EC50:  2.60nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29318(oxazolidin-2-imine, 6a)
Affinity DataKi:  0.800nM ΔG°:  -51.4kJ/mole EC50:  4.80nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18178(4-[(1R,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/mole EC50:  2.5nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18177(4-[(1S,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/mole EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18184(4-[(1R,7R,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole EC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440849(CHEMBL2431588)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18173(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/mole EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18176(4-[(1S,7S,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole EC50:  5.20nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18176(4-[(1S,7S,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/mole EC50:  5.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18180(4-[(1R,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/mole EC50:  7.10nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18181(4-[(1S,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/mole EC50:  48nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29326(guanidine derivative, 12)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/mole EC50:  44nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18174(4-[(7R,7aR)-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18173(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  2.11nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18186(4-[(1S,7R,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/mole EC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18175(4-[(3aR,4R,6aS)-4-hydroxy-1-oxo-octahydrocyclopent...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/mole EC50:  20nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29322(oxazolidin-2-imine, 6e)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/mole EC50:  1.10nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18185(4-[(1R,7R,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/mole EC50:  7.40nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440822(CHEMBL2431602)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18182(4-[(1S,7R,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-...)
Affinity DataKi:  2.90nM ΔG°:  -48.2kJ/mole EC50:  13nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18171(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18171(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/mole EC50:  2.30nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18179(4-[(1R,7S,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/mole EC50:  87nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440843(CHEMBL2431614)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18174(4-[(7R,7aR)-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/mole EC50:  6.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440846(CHEMBL2431603)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50215716(2-chloro-4-((3aS,4R)-4-hydroxy-3a-methyl-1,1,3-tri...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440848(CHEMBL2431604)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440847(CHEMBL2431595)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440822(CHEMBL2431602)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29325(guanidine derivative, 11)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/mole EC50:  1.80E+3nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440845(CHEMBL2431611)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18173(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole EC50:  7.80nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50215714(2-chloro-4-((3aR,4R)-4-hydroxy-1,1-dioxo-tetrahydr...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440825(CHEMBL2431589)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440842(CHEMBL2431609)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29328(cyanoguanidine, 15)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/mole EC50:  1.11E+3nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440841(CHEMBL2431598)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM29327(guanidine derivative, 13)
Affinity DataKi:  19nM ΔG°:  -43.6kJ/molepH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50215710(2-chloro-4-((3aR,4S)-4-hydroxy-3-methyl-1,1-dioxo-...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18187(4-[(1R,7R,7aR)-7-hydroxy-3-oxo-1-(propan-2-yl)-hex...)
Affinity DataKi:  23nM ΔG°:  -43.2kJ/mole EC50:  108nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50440823(CHEMBL2431597)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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