Compile Data Set for Download or QSAR
maximum 50k data
Found 728 with Last Name = 'nogle' and Initial = 'l'
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319772((2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-trimethyl-6...)
Affinity DataKi:  0.0500nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319776((2,2'-dimethylbiphenyl-4-yl)((1S,5R)-1,3,3-trimeth...)
Affinity DataKi:  0.0600nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319799((4-(1H-indol-3-yl)-3-methoxyphenyl)((1S,5R)-1,3,3-...)
Affinity DataKi:  0.100nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  0.280nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319774((3-chloro-2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-tr...)
Affinity DataKi:  0.310nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85095(CAS_151171 | CONIVAPTAN | NSC_151171 | YM087)
Affinity DataKi:  0.360nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319788(CHEMBL1084325 | N-(2'-methoxy-4'-((1S,5R)-1,3,3-tr...)
Affinity DataKi:  0.370nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85095(CAS_151171 | CONIVAPTAN | NSC_151171 | YM087)
Affinity DataKi:  0.430nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.5nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319780((2-chloro-5-methoxy-2'-methylbiphenyl-4-yl)((1S,5R...)
Affinity DataKi:  0.540nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007659(CHEMBL3233142)
Affinity DataKi:  0.540nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319782((2-methoxy-2',6'-dimethylbiphenyl-4-yl)((1S,5R)-1,...)
Affinity DataKi:  0.600nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.700nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319806((3-methoxy-4-(quinolin-8-yl)phenyl)((1S,5R)-1,3,3-...)
Affinity DataKi:  0.710nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319797((4-(benzo[b]thiophen-3-yl)-3-methoxyphenyl)((1S,5R...)
Affinity DataKi:  0.790nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319792((2-methoxy-4'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-t...)
Affinity DataKi:  0.800nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007666(CHEMBL3233432)
Affinity DataKi:  0.890nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007667(CHEMBL3233143)
Affinity DataKi:  0.940nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H1.0(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  1nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007662(CHEMBL3233427)
Affinity DataKi:  1nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319787(2'-methoxy-N-methyl-4'-((1S,5R)-1,3,3-trimethyl-6-...)
Affinity DataKi:  1.03nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319803((4-(2-chloro-1,2-pyridin-3-yl)-3-methoxyphenyl)((1...)
Affinity DataKi:  1.07nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007718(CHEMBL3233430)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007665(CHEMBL3233431)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  1.60nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007661(CHEMBL3233423)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  2nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone H1.0(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  2nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007668(CHEMBL3233144)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319791((4'-chloro-2-methoxy-2'-methylbiphenyl-4-yl)((1S,5...)
Affinity DataKi:  2.26nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  2.30nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007680(CHEMBL3233409)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  2.5nMAssay Description:Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50007683(CHEMBL3233412)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319784((2''-Methoxy-[1,1',2',1'']terphenyl-4''-yl)-((1S,5...)
Affinity DataKi:  2.60nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 728 total ) | Next | Last >>
Jump to: