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Found 57 with Last Name = 'o''brien' and Initial = 'l'
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325723((R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazo...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325722((R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  5.5nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293055((R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(triflu...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325719((R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(...)
Affinity DataIC50:  6.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293055((R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(triflu...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325718(2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trif...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293054((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325722((R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N...)
Affinity DataIC50:  17nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325719((R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(...)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325720((R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293051((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293053((R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluorom...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293051((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293053((R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluorom...)
Affinity DataIC50:  23nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325720((R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N...)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293052((R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluorom...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293054((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(...)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325718(2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trif...)
Affinity DataIC50:  65nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325723((R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazo...)
Affinity DataIC50:  69nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293052((R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluorom...)
Affinity DataIC50:  120nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293051((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Affinity DataIC50:  140nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293051((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Affinity DataIC50:  140nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293034((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-eth...)
Affinity DataIC50:  270nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  270nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293035((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-met...)
Affinity DataIC50:  270nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293049((R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-me...)
Affinity DataIC50:  290nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  370nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293049((R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-me...)
Affinity DataIC50:  440nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50061306((3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataIC50:  530nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293059((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-...)
Affinity DataIC50:  540nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293046((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-p-tolylpyrrol...)
Affinity DataIC50:  680nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293047((R)-N2-(4-Chlorobenzyl)-N1-(4-fluorophenyl)-N2-met...)
Affinity DataIC50:  700nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293048((R)-N2-(4-Chlorobenzyl)-N1-(4-cyanophenyl)-N2-meth...)
Affinity DataIC50:  720nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50325721((R)-2-(1-(4-chlorobenzyl)-3-methyl-1H-1,2,4-triazo...)
Affinity DataIC50:  810nMAssay Description:Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293041((R)-N2-(4-Fluorobenzyl)-N1-(4-chlorophenyl)-N2-met...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293050((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-(3-(trifluoro...)
Affinity DataIC50:  2.95E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293033((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-pro...)
Affinity DataIC50:  3.60E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293044((R)-N2-(4-Chloro-3-methylbenzyl)-N1-(4-chloropheny...)
Affinity DataIC50:  4.00E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50114971(CHEMBL294938 | [(3R,5R,6R)-4-Benzyloxy-5-hydroxy-6...)
Affinity DataIC50:  4.48E+3nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50114968(((3R,5R,6R)-4-Benzyloxy-3,5-dihydroxy-6-methoxy-te...)
Affinity DataIC50:  4.66E+3nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293045((2R)-N1-(4-Chlorophenyl)-N2-[1-(4-chlorophenyl)eth...)
Affinity DataIC50:  4.70E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50114970((6R,7R,8aR)-8-Benzyloxy-6-methoxy-2-phenyl-hexahyd...)
Affinity DataIC50:  4.85E+3nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293042((R)-N2-(4-Methylbenzyl)-N1-(4-chlorophenyl)-N2-met...)
Affinity DataIC50:  5.70E+3nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50114969(CHEMBL51564 | N-[(3R,5R,6R)-4-Benzyloxy-5-hydroxy-...)
Affinity DataIC50:  7.74E+3nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50114965(CHEMBL52487 | N-((3S,5R,6S)-3,4,5-Trihydroxy-6-phe...)
Affinity DataIC50:  8.95E+3nMAssay Description:Compound was tested for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293038((R)-N2-(4-Cyanobenzyl)-N1-(4-chlorophenyl)-N2-meth...)
Affinity DataIC50: >1.30E+4nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293058((S)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[4-(trifluoro...)
Affinity DataIC50: >2.80E+4nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50293056(CHEMBL515927 | N2-(4-Chlorobenzyl)-N2-methyl-N1-[4...)
Affinity DataIC50: >2.80E+4nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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