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Found 13 with Last Name = 'oamppound39connor' and Initial = 'sj'
LigandPNGBDBM17327((2S)-2-({1-[benzyl(1,3-thiazol-5-ylmethyl)carbamoy...)
Affinity DataIC50:  0.560nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17328((2S)-2-[(1-{[3-cyclohexyl-1-(1,3-thiazol-5-yl)prop...)
Affinity DataIC50:  0.710nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50:  0.920nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17325((2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}...)
Affinity DataIC50:  1.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM17333(1-[(2R)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50:  1.20nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17326((2S)-2-[(1-{2-[benzyl(1,3-thiazol-5-ylmethyl)amino...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17334(1-[(2S)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM17331(1-[(2R)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazo...)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17330(1-(2-{benzyl[(1-methyl-1H-imidazol-5-yl)methyl]ami...)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17332(1-[(2S)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazo...)
Affinity DataIC50:  310nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17329(1-(2-{[(4-cyanophenyl)methyl][(1-methyl-1H-imidazo...)
Affinity DataIC50:  560nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50:  1.60E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17333(1-[(2R)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50:  3.50E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed