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Found 1316 with Last Name = 'ogawa' and Initial = 'a'
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419907((S)-2-(1-(3-AMMONIO-1H-INDAZOLE-6-CARBOXAMIDO)-2-P...)
Affinity DataKi:  0.900nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419910(US10472344, Example 4)
Affinity DataKi:  1.30nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330035(Methyl [(7S)-7-[6-(aminomethyl)-1-oxo-3,4-dihydroi...)
Affinity DataKi:  2.40nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM285852(5-(2-{3-[5-chloro-2- (1H-tetrazol-1- yl)phenyl]-1-...)
Affinity DataKi:  3.08nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419908(US10472344, Example 2)
Affinity DataKi:  3.60nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330036(US9663527, Example 2)
Affinity DataKi:  3.90nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352466(US9809545, 3Bd)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352458(US9809545, 1Bc)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352464(US9809545, 3g)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352476(US9809545, 4Cl)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352478(US9809545, 5b)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352460(US9809545, 1Ef)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352469(US9809545, 4Aa)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352461(US9809545, 1Ff)
Affinity DataKi:  6nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352459(US9809545, 1Ea)
Affinity DataKi:  6nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419912(US10472344, Example 6)
Affinity DataKi:  6.90nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352473(US9809545, 4Bn)
Affinity DataKi:  18nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419913(US10472344, Example 7)
Affinity DataKi:  20nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419907((S)-2-(1-(3-AMMONIO-1H-INDAZOLE-6-CARBOXAMIDO)-2-P...)
Affinity DataKi:  25nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419910(US10472344, Example 4)
Affinity DataKi:  36nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352472(US9809545, 4Bi)
Affinity DataKi:  39nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352474(US9809545, 4Bp)
Affinity DataKi:  54nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330037(US9663527, Example 3)
Affinity DataKi:  70nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419911(US10472344, Example 5)
Affinity DataKi:  83nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419908(US10472344, Example 2)
Affinity DataKi:  105nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419909(US10472344, Example 3)
Affinity DataKi:  144nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352470(US9809545, 4Af)
Affinity DataKi:  154nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330038(US9663527, Example 4)
Affinity DataKi:  170nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419912(US10472344, Example 6)
Affinity DataKi:  219nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352479(US9809545, 6h)
Affinity DataKi:  240nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352471(US9809545, 4Ar)
Affinity DataKi:  275nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352480(US9809545, 6Aa)
Affinity DataKi:  280nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352465(US9809545, 3Bc)
Affinity DataKi:  320nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352456(US9809545, 1Al | methyl (4-((2-(4-(5-chloro-2-nitr...)
Affinity DataKi:  340nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352462(US9809545, 2d)
Affinity DataKi:  370nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352455(US9809545, 1Ag | ethyl (4-(2-(4-(5-chloro-2-nitrop...)
Affinity DataKi:  400nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352468(US9809545, 3Ce)
Affinity DataKi:  417nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM419913(US10472344, Example 7)
Affinity DataKi:  516nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352467(US9809545, 3Ca)
Affinity DataKi:  825nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352477(US9809545, 4Co)
Affinity DataKi:  1.04E+3nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352463(US9809545, 2Af)
Affinity DataKi:  7.75E+3nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352457(US9809545, 1Aw)
Affinity DataKi: >1.00E+4nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0650nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM345099(4-[(2-{5-[5-chloro-2-(1H- tetrazol-1-yl)phenyl]-1-...)
Affinity DataIC50:  0.0700nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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