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Found 754 with Last Name = 'okamoto' and Initial = 'o'
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244370((7R,9S)-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)m...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244371((7R,9S)-7-((4-(2-chlorophenyl)piperidin-1-yl)methy...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243726((7R,9S)-7-(((3S,4R)-3-methyl-4-o-tolylpiperidin-1-...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243729((7R,9S)-7-(((3S,4S)-4-(4-fluoro-2-methylphenyl)-3-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243727((7R,9S)-7-(((3S,4R)-3-(hydroxymethyl)-4-o-tolylpip...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243730((7R,9S)-7-(((3R,4R)-4-(2-chloro-4-fluorophenyl)-3-...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244297(CHEMBL513585 | cis-1-methyl-7-((4-o-tolylpiperidin...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243728((7R,9S)-7-(((3S,4S)-3-hydroxy-4-o-tolylpiperidin-1...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243887((-)-(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxy-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244336((6R,8S)-6-((4-o-tolylpiperidin-1-yl)methyl)-5,6,7,...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244334((7R)-9-methyl-7-((4-o-tolylpiperidin-1-yl)methyl)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244334((7R)-9-methyl-7-((4-o-tolylpiperidin-1-yl)methyl)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244295((-)-7-((4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-te...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244295((-)-7-((4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-te...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095493(CHEMBL276169 | N-(1-Cyano-azetidin-3-ylmethyl)-ben...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244372((7R,9S)-7-((4-o-tolylpiperazin-1-yl)methyl)-6,7,8,...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243886((6R,8S)-6-(((3R,4R)-4-(4-fluoro-2-methylphenyl)-3-...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244335((3R)-3-{[4-(2-methylphenyl)piperidin-1-yl]methyl}-...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244373((7R,9S)-7-((4-phenylpiperidin-1-yl)methyl)-6,7,8,9...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244333((R)-7-((4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-te...)
Affinity DataKi:  49nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50243797((6R,8S)-6-(((3R,4R)-3-hydroxy-4-o-tolylpiperidin-1...)
Affinity DataKi:  51nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244374((7R,9S)-7-((4-methyl-4-phenylpiperidin-1-yl)methyl...)
Affinity DataKi:  58nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(CHEMBL275080 | N-(1-Cyano-pyrrolidin-3-yl)-benzene...)
Affinity DataKi:  90nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)
Affinity DataKi:  140nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataKi:  280nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataKi:  380nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258001(CHEMBL492370 | N-(3,4-dichlorophenyl)-1-(methylsul...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nM EC50:  0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258232(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258232(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Affinity DataIC50:  0.570nMAssay Description:Binding affinity to human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296580((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296581((1S,3R)-N-((1-ethyl-5-(5-fluoro-6-methylpyridin-3-...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268532(3-oxo-N-(5-phenylpyrimidin-2-yl)-3H-spiro[isobenzo...)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [125I]PYY from rat NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50298636(1-(Methylsulfonyl)-N-[4-(phenylcarbonyl)phenyl]-1,...)
Affinity DataIC50:  0.680nMAssay Description:Binding affinity to human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268739(CHEMBL524085 | N-(3-(4-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  0.690nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29994(2-Cyclohexylcarbonylbenzimidazole, 7e)
Affinity DataIC50:  0.800nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nM EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258191(1-(Methylsulfonyl)-N-(6-phenylpyridin-3-yl)-1,2-di...)
Affinity DataIC50:  0.820nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258191(1-(Methylsulfonyl)-N-(6-phenylpyridin-3-yl)-1,2-di...)
Affinity DataIC50:  0.820nMAssay Description:Binding affinity to human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268737(CHEMBL526084 | N-(3-(2-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  0.830nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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