Found 55 with Last Name = 'olefsky' and Initial = 'jm' 
Affinity DataKi: 63nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 158nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 158nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 251nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 251nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 794nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of norepinephrine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 2.83E+3nMAssay Description:Inhibition of adrenergic alpha2A receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6.28E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8.02E+3nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 2.90E+3nMAssay Description:Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 4.62E+4nMAssay Description:Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT3 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT3 by mass spectrometry assayMore data for this Ligand-Target Pair
Affinity DataEC50: 126nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT3 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT3 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT2 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT2 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >3.00E+5nMAssay Description:Activation of SIRT2 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 160nMAssay Description:Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 360nMAssay Description:Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 1.62E+4nMAssay Description:Binding affinity to human SIRT1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris Pharmaceuticals
Curated by ChEMBL
Sirtris Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 1.62E+4nMAssay Description:Binding affinity to SIRT1More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 1.59E+3nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 794nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 251nMAssay Description:Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 2.57E+5nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...More data for this Ligand-Target Pair
