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Found 479 with Last Name = 'palumbi' and Initial = 'mc'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316229(2-(1,2,3,4-tetrahydroisoquinolin-6-yl)-2H-indazole...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316242(2-(4-(piperidin-1-ylmethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316237(2-(4-{[(2-Fluoroethyl)amino]methyl}phenyl)-2H-inda...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP2 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316230(2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-2H-indazole...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183200(3-chloro-4-(2-(1-mesityl-1H-tetrazol-5-ylthio)acet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183196(2-(1-mesityl-1H-tetrazol-5-ylthio)-N-(2-nitropheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183190(2-(1-(2-bromo-4-methylphenyl)-1H-tetrazol-5-ylthio...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183217(CHEMBL206522 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183199(2-(1-(3-chloro-2-methylphenyl)-1H-tetrazol-5-ylthi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316228(2-(4-(pyrrolidin-2-yl)phenyl)-2H-indazole-7-carbox...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316234(2-(4-(1-(methylamino)ethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316244(2-(4-((dimethylamino)methyl)phenyl)-2H-indazole-7-...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306210(2-(4-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183211(CHEMBL205152 | N-(4-chloro-2-nitrophenyl)-2-(1-mes...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183201(CHEMBL379722 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183193(2-(1-(2,6-dichlorophenyl)-1H-tetrazol-5-ylthio)-N-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1807225 | CHEMBL1813106)
Affinity DataIC50:  4nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183210(2-(1-(2,5-dichlorophenyl)-1H-tetrazol-5-ylthio)-N-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316238(2-{4-[(Ethylamino)methyl]phenyl}-2H-indazole-7-car...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316243(2-[4-(Pyrrolidin-1-ylmethyl)phenyl]-2H-indazole-7-...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350335(CHEMBL1813107)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1807225 | CHEMBL1813106)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480723(CHEMBL561533)
Affinity DataIC50:  5nMAssay Description:Inhibition of BODIPY-cyclopamine to Smo in human HEK293 Flag-Smo cells in presence of 2% FCSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  5nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM27606(2-{[1-(naphthalen-1-yl)-1H-1,2,3,4-tetrazol-5-yl]s...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183207(CHEMBL377010 | N-(2-chlorophenyl)-2-(1-mesityl-1H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183198(3-chloro-N-(3-(dimethylamino)propyl)-4-(2-(1-mesit...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316231(2-(3-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316239(2-(4-(((2-(dimethylamino)ethyl)(methyl)amino)methy...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  6nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316235(2-(4-((isopropylamino)methyl)phenyl)-2H-indazole-7...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  7nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50245989(1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183206(CHEMBL381513 | N-(2-bromophenyl)-2-(1-mesityl-1H-t...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350338(CHEMBL1813110)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352269(CHEMBL1822466)
Affinity DataIC50:  8nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  9nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316227(2-(4-(piperidin-4-yl)phenyl)-2H-indazole-7-carboxa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183212(CHEMBL383088 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183213(2-(1-(2-chloro-5-fluorophenyl)-1H-tetrazol-5-ylthi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295219(2-(4-methyl-1,4-diazepane-1-carbonyl)pyrazolo[1,5-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352270(CHEMBL1822465)
Affinity DataIC50:  10nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352269(CHEMBL1822466)
Affinity DataIC50:  10nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349259(CHEMBL1807222 | CHEMBL1813105)
Affinity DataIC50:  12nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183205(2-(1-(2,3-dichlorophenyl)-1H-tetrazol-5-ylthio)-N-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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