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Found 794 with Last Name = 'park' and Initial = 'sm'
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588041(9-bromo-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin...)
Affinity DataIC50:  0.350nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588031(9-chloro-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridi...)
Affinity DataIC50:  0.360nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50:  0.590nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588032(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588043((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  1.21nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  1.36nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502507(CHEMBL4475659)
Affinity DataIC50: <2nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588046((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  2.45nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588044((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.5nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588050((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  2.70nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27730((2S,3R)-3-(tert-butoxy)-2-{[4-(4-methoxyphenyl)-2-...)
Affinity DataIC50:  3nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502502(CHEMBL4528905)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27747((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Affinity DataIC50:  3nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588047((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.40nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588049((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  3.80nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27743((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27746((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27745((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502506(CHEMBL4460841)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)
Affinity DataIC50:  5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256329(1-(3-(3-mesitylureido)-2-naphthamido)cyclooctaneca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50255975((S)-2-cyclohexyl-2-(3-(3-(2,6-dichloro-4-(trifluor...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50255977((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256669((2S,3R)-2-(3-(3-mesitylureido)-2-naphthamido)-3-(1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418124(CHEMBL1760428)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27726((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1802(2-Amino-6-arylthiobenzonitrile deriv. 3v, 739W94 |...)
Affinity DataIC50:  7nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27726((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27734((2S,3R)-3-(tert-butoxy)-2-{[4-(4-fluorophenyl)-2-{...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27744((2S,3R)-3-(tert-butoxy)-2-{[4-(3,4-difluorophenyl)...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418148(CHEMBL1760411)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of rat FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502516(CHEMBL4470436)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27731((2S,3R)-3-(tert-butoxy)-2-{[4-(3-methoxyphenyl)-2-...)
Affinity DataIC50:  8nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588043((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  8.31nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256573((S)-2-(3-(3-mesitylureido)-2-naphthamido)-5-methyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502509(CHEMBL4548610)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1805(2-Amino-6-arylthiobenzonitrile deriv. 3y | 2-amino...)
Affinity DataIC50:  10nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256169((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27742((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27729((2S,3R)-3-(tert-butoxy)-2-[(4-phenyl-2-{[(2,4,6-tr...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588044((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502517(CHEMBL4458025)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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