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Found 407 with Last Name = 'phillips' and Initial = 'aj'
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50:  3.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))
Affinity DataIC50:  6nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192713(HG-9-91-01 derivative, 2)
Affinity DataIC50:  19.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192715(US11725011, Compound YKL-05-96 | YKL-05-096 (4))
Affinity DataIC50:  34nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataIC50:  40nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192717(HG-9-91-01 derivative, 6)
Affinity DataIC50:  150nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192718(HG-9-91-01 derivative, 7)
Affinity DataIC50: >7.00E+3nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataEC50:  220nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192713(HG-9-91-01 derivative, 2)
Affinity DataEC50:  3nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))
Affinity DataEC50:  11nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192715(US11725011, Compound YKL-05-96 | YKL-05-096 (4))
Affinity DataEC50:  70nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataEC50:  460nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192717(HG-9-91-01 derivative, 6)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-10(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192718(HG-9-91-01 derivative, 7)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575232(US11459335, Compound 29 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575233(US11459335, Compound 30 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575234(US11459335, Compound 31 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575235(US11459335, Compound 32 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575236(US11459335, Compound 33 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575237(US11459335, Compound 34 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575238(US11459335, Compound 35 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575239(US11459335, Compound 36 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575240(US11459335, Compound 37 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575241(US11459335, Compound 38 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575242(US11459335, Compound 39 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575243(US11459335, Compound 40 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575244(US11459335, Compound 41 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575245(US11459335, Compound 42 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575246(US11459335, Compound 43 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575248(US11459335, Compound 45 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575249(US11459335, Compound 46 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575250(US11459335, Compound 47 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575251(US11459335, Compound 48 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575252(US11459335, Compound 49 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575253(US11459335, Compound 50 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575254(US11459335, Compound 51 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575255(US11459335, Compound 52 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575256(US11459335, Compound 53 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575257(US11459335, Compound 54 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575258(US11459335, Compound 55 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575259(US11459335, Compound 56 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575260(US11459335, Compound 57 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575261(US11459335, Compound 58 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575262(US11459335, Compound 59 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575263(US11459335, Compound 60 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575264(US11459335, Compound 61 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575265(US11459335, Compound 62 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575266(US11459335, Compound 63 | US20230279023, Compound ...)
Affinity DataKd:  3.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575267(US11459335, Compound 64 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
C4 Therapeutics

US Patent
LigandPNGBDBM575268(US11459335, Compound 65 | US20230279023, Compound ...)
Affinity DataKd: <1.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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