Compile Data Set for Download or QSAR
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Found 479 with Last Name = 'rasa' and Initial = 'c'
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365815(CHEMBL1956994)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365814(CHEMBL1956993)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365831(CHEMBL1957010)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365822(CHEMBL1957001)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365809(CHEMBL1956990)
Affinity DataKi:  0.160nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365812(CHEMBL1956991)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365820(CHEMBL1956999)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365828(CHEMBL1957007)
Affinity DataKi:  0.260nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365830(CHEMBL1957009)
Affinity DataKi:  0.270nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365821(CHEMBL1957000)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365818(CHEMBL1956997)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365824(CHEMBL1957003)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365826(CHEMBL1957005)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365813(CHEMBL1956992)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365827(CHEMBL1957006)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365810(CHEMBL1956987)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365829(CHEMBL1957008)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365811(CHEMBL1956988)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365817(CHEMBL1956996)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365816(CHEMBL1956995)
Affinity DataKi:  3.10nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365825(CHEMBL1957004)
Affinity DataKi:  3.10nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365819(CHEMBL1956998)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365832(CHEMBL1957011)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058528((S)-3-[((1S,9S)-9-Benzoylamino-6,10-dioxo-octahydr...)
Affinity DataKi:  5nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058527((S)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylam...)
Affinity DataKi:  6nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365823(CHEMBL1957002)
Affinity DataKi:  6.60nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50365808(CHEMBL1956989)
Affinity DataKi:  6.70nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50176519((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50286304((R)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058529((S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058531((S)-3-[((1S,9S)-9-Benzyloxycarbonylamino-6,10-diox...)
Affinity DataKi:  25nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of wild type p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477513(CHEMBL392246)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of wild type p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477516(BMS-433796 | CHEMBL247361)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477528(CHEMBL397844)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477531(CHEMBL396808)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477536(CHEMBL247155)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477526(CHEMBL429292)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50223758(CHEMBL58925)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125393(CHEMBL57014)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477521(CHEMBL439210)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477516(BMS-433796 | CHEMBL247361)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477517(CHEMBL246785)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50477534(CHEMBL397394)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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