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Found 2890 with Last Name = 'reed' and Initial = 'j'
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020711(CHEMBL3291216)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020711(CHEMBL3291216)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020709(CHEMBL3291215)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020708(CHEMBL3291214)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020708(CHEMBL3291214)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020709(CHEMBL3291215)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human cloned mu opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020711(CHEMBL3291216)
Affinity DataKi:  0.490nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020709(CHEMBL3291215)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Oslo

Curated by ChEMBL
LigandPNGBDBM50020708(CHEMBL3291214)
Affinity DataKi:  8nMAssay Description:Binding affinity to human cloned delta opioid receptor expressed in CHO cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50052442((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50196190(1-[2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-4...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]CCK8S from human CCK2RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50196191(4-[4-iodo-2-[(5-quinoxalinylsulfonyl)amino]benzoyl...)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]CCK8S from human CCK2RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50196157(1-[2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-4...)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]CCK8S from human CCK2RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44264(CHEMBL1621842 | MLS-0390982.0001 | cid_25241639 | ...)
Affinity DataKi:  55nMAssay Description:Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44264(CHEMBL1621842 | MLS-0390982.0001 | cid_25241639 | ...)
Affinity DataKi:  60nMAssay Description:Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50478086(CHEMBL261682)
Affinity DataKi:  63nMAssay Description:Displacement of [125I]CCK8S from human CCK2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50478090(CHEMBL259762)
Affinity DataKi:  79nMAssay Description:Displacement of [125I]CCK8S from human CCK2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330256(5,5'-Bis(4-chlorobenzyl)-6,6',7,7''-tetrahydroxy-3...)
Affinity DataKi:  110nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44263(CHEMBL1622024 | MLS-0390980.0001 | cid_25241637 | ...)
Affinity DataKi:  120nMAssay Description:Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330251(CHEMBL1269012 | N5,N5'-Bis(4-ethylphenethyl)-6,6',...)
Affinity DataKi:  140nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330258(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tet...)
Affinity DataKi:  150nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330257(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(2-ph...)
Affinity DataKi:  150nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataKi:  160nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330251(CHEMBL1269012 | N5,N5'-Bis(4-ethylphenethyl)-6,6',...)
Affinity DataKi:  160nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  170nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50289150(Acetic acid (7E,11E)-(1S,2R,4R,14S,15R)-4,8,12-tri...)
Affinity DataKi:  170nMAssay Description:Kinetic parameter for inihibiton of farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataKi:  190nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330258(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tet...)
Affinity DataKi:  210nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330251(CHEMBL1269012 | N5,N5'-Bis(4-ethylphenethyl)-6,6',...)
Affinity DataKi:  210nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330257(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(2-ph...)
Affinity DataKi:  230nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataKi:  230nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330256(5,5'-Bis(4-chlorobenzyl)-6,6',7,7''-tetrahydroxy-3...)
Affinity DataKi:  230nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330257(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(2-ph...)
Affinity DataKi:  240nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM13151((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  250nMAssay Description:Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330247(6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimet...)
Affinity DataKi:  250nMAssay Description:Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50388975(CHEMBL2063869)
Affinity DataKi:  260nMAssay Description:Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330256(5,5'-Bis(4-chlorobenzyl)-6,6',7,7''-tetrahydroxy-3...)
Affinity DataKi:  270nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50436878(CHEMBL2403872)
Affinity DataKi:  290nMAssay Description:Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  310nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330258(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tet...)
Affinity DataKi:  310nMAssay Description:Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44291((2S)-N-(diphenylmethyl)-1-[(2S)-4-methyl-2-[[(2S)-...)
Affinity DataKi:  350nMAssay Description:Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKi:  370nMAssay Description:Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44276((2S)-N-[(1S)-1-[(2S)-2-(anilinocarbamoyl)pyrrolidi...)
Affinity DataKi:  390nMAssay Description:Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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