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Found 193 with Last Name = 'reigan' and Initial = 'p'
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  32nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50105838(FENOBAM)
Affinity DataKi:  33nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Escherichia coli)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122770(6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...)
Affinity DataKi:  800nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450061(CHEMBL4166199)
Affinity DataKi:  1.88E+3nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450078(CHEMBL4167825)
Affinity DataKi:  3.08E+3nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450074(CHEMBL4171187)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450075(CHEMBL4174628)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450060(CHEMBL4172276)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450059(CHEMBL4160584)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450076(CHEMBL4163974)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Montana

Curated by ChEMBL
LigandPNGBDBM50450077(CHEMBL4164391)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of bovine xanthine oxidase using hypoxanthine as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of bovine xanthine oxidase using xanthine as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  1.90nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  3nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50111384(CHEMBL3604794)
Affinity DataIC50:  4nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  4nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50111384(CHEMBL3604794)
Affinity DataIC50:  5nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50111384(CHEMBL3604794)
Affinity DataIC50:  6nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  13nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  15nMAssay Description:Inhibition of RSK4 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM642525(US11851436, Compound A1-8)
Affinity DataIC50:  15.7nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568111(CHEMBL4878141 | US11851436, Compound A1-12)
Affinity DataIC50:  16nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564453(CHEMBL4794096)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human His6-tagged AMPK alpha2 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM642526(US11851436, Compound A1-9)
Affinity DataIC50:  17.8nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK3 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568112(CHEMBL4851452)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568106(CHEMBL4849660 | US11851436, Compound A1-4)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568105(CHEMBL4858455 | US11851436, Compound A1-3)
Affinity DataIC50:  18.4nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Escherichia coli)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against thymidine phosphorylase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Escherichia coli)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Thymidine phosphorylase from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122771(2-Amino-1-(5-chloro-2,6-dioxo-1,2,3,6-tetrahydro-p...)
Affinity DataIC50:  21nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564457(CHEMBL4800500)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human His6-tagged AMPK alpha2 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  22.6nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  23nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of RSK2 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568104(CHEMBL4858257 | US11851436, Compound A1-2)
Affinity DataIC50:  24.6nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568105(CHEMBL4858455 | US11851436, Compound A1-3)
Affinity DataIC50:  25nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568110(CHEMBL4865383 | US11851436, Compound A1-11)
Affinity DataIC50:  25.7nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568114(CHEMBL4857399)
Affinity DataIC50:  26nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  31nMAssay Description:Inhibition of RSK1 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant human His6-tagged AMPK alpha2 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568111(CHEMBL4878141 | US11851436, Compound A1-12)
Affinity DataIC50:  34.7nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50568115(CHEMBL4864190)
Affinity DataIC50:  35nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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