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Found 316 with Last Name = 'reuberson' and Initial = 'j'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113399(4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-...)
Affinity DataKi:  423nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113373(2-Cyclopentyloxy-4-(1,2-diphenyl-ethyl)-1-methoxy-...)
Affinity DataKi:  1.17E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113366(4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113362(1-{3-[1-((R)-3-Cyclopentyloxy-4-methoxy-phenyl)-2-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278725(CHEMBL4172769)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278758(CHEMBL4167445)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113380(4-{(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-[4-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278799(CHEMBL4162364)
Affinity DataIC50:  1nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50:  1nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278793(CHEMBL4160218)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113389(CHEMBL285766 | N-{4-[(R)-1-(3-Cyclopentyloxy-4-met...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113372(4-[(S)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-thi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Canis lupus familiaris)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113377(1-{4-[(R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50:  4nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278797(CHEMBL4160846)
Affinity DataIC50:  4nMAssay Description:In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278794(CHEMBL4175323)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278727(CHEMBL4173046)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113363(CHEMBL286921 | N-{4-[(R)-1-(3-Cyclopentyloxy-4-met...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113378(4-[(S)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-fur...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 4(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113381(4-[(R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113390(CHEMBL286118 | Pyrrolidine-1-carboxylic acid {3-[(...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113387(4-[(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phe...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113386(CHEMBL35011 | Propane-2-sulfonic acid {4-[(R)-1-(3...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113392(CHEMBL36559 | N-{4-[(R)-1-(3-Cyclopentyloxy-4-meth...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457867(CHEMBL4203566)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113369(CHEMBL286421 | N-{4-[(R)-1-(3-Cyclopentyloxy-4-met...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278787(CHEMBL4173861)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278801(CHEMBL4165356)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457868(CHEMBL4202450)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113404(4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-(3-fluo...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113396(4-[(R)-2-(3-cyclopentyloxy-4-methoxy-phenyl)-2-pyr...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457876(CHEMBL4209793)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50005005(CHEMBL2397317)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113391(CHEMBL287359 | N-{4-[(R)-1-(3-Cyclopentyloxy-4-met...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457850(CHEMBL4203041)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295759(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295752(4-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrro...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113364(CHEMBL416399 | N-(methylsulfonyl)-N-[4-(1-{3-cyclo...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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