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Found 320 with Last Name = 'riviello' and Initial = 'c'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(RAT)
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  325nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033318(Benzyl-(6-ethynyl-2-imidazol-1-yl-quinazolin-4-yl)...)
Affinity DataIC50:  0.530nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311657(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50277112(3-[1-Oxo-6-(1,2,3,4-tetrahydro-benzo[4,5]imidazo[1...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to human integrin alphavbeta3 receptor by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345056(2-(6-(3-((dimethylamino)methyl)phenyl)-2-(4-fluoro...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345045(CHEMBL1778950 | N-isopropyl-2-(2-(3-methoxyphenyl)...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50277111(3-Benzo[1,3]dioxol-5-yl-3-[1-oxo-6-(1,2,3,4-tetrah...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to human integrin alphavbeta3 receptor by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(RAT)
Msd

Curated by ChEMBL
LigandPNGBDBM50338810(CHEMBL1684573 | N-isopropyl-2-(2-(3-methoxyphenyl)...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033343(Benzyl-(6-bromo-2-imidazol-1-yl-quinazolin-4-yl)-a...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033313(Benzyl-(2-imidazol-1-yl-6-nitro-quinazolin-4-yl)-a...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033312(Benzyl-(6-chloro-2-imidazol-1-yl-quinazolin-4-yl)-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325890(CHEMBL1224536 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338810(CHEMBL1684573 | N-isopropyl-2-(2-(3-methoxyphenyl)...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311656(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338810(CHEMBL1684573 | N-isopropyl-2-(2-(3-methoxyphenyl)...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338798(CHEMBL1684561 | N-isopropyl-2-(2-(3-methoxyphenyl)...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(RAT)
Msd

Curated by ChEMBL
LigandPNGBDBM50338811(2-(2-(3-chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)p...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311657(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325894(CHEMBL1224615 | N-(3-((6-(benzo[d][1,3]dioxol-4-yl...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50277112(3-[1-Oxo-6-(1,2,3,4-tetrahydro-benzo[4,5]imidazo[1...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to human integrin alphavbeta5 receptor by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338799(2-(2-(3-chlorophenyl)-6-(3-morpholinopropoxy)-4-ox...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338811(2-(2-(3-chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)p...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311644(1-(9-(2,6-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338811(2-(2-(3-chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)p...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345055(2-(6-(5-((dimethylamino)methyl)-2-fluorophenyl)-2-...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325888(CHEMBL1224534 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325892(CHEMBL1224613 | N-(3-((6-(benzo[d][1,3]dioxol-4-yl...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50277098(3-[1-Oxo-6-(1,2,3,4-tetrahydro-benzo[4,5]imidazo[1...)
Affinity DataIC50:  7nMAssay Description:Binding affinity to human integrin alphavbeta3 receptor by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311640(1-(8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50156754((S)-N-methoxy-4-methyl-3-(4-(methyl(neopentyl)amin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345043(2-(6-(3-((dimethylamino)methyl)phenyl)-2-(3-methox...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345048(2-(2-(3-chlorophenyl)-4-oxo-6-(3-(piperidin-1-ylme...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033306(Benzyl-(6-nitro-2-pyridin-3-yl-quinazolin-4-yl)-am...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033328(Benzyl-(2-imidazol-1-yl-6-methylsulfanyl-quinazoli...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311639(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50277111(3-Benzo[1,3]dioxol-5-yl-3-[1-oxo-6-(1,2,3,4-tetrah...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to human integrin alphavbeta5 receptor by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311655(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338780(CHEMBL1684408 | N-(cyclopropylmethyl)-2-(2-(3-meth...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50156743((S)-N-hydroxy-4-methyl-3-(4-(methyl(neopentyl)amin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor

Curated by ChEMBL
LigandPNGBDBM50033293(Benzyl-(2-imidazol-1-yl-6-methoxy-quinazolin-4-yl)...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311642(1-(9-(2,3-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50338808(CHEMBL1684571 | N-cyclopropyl-2-(2-(3-methoxypheny...)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50156750(CHEMBL376506 | DEL-A, 5 | N-methoxy-4-methyl-3-(4-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345046(2-(2-(3-chlorophenyl)-6-(3-((dimethylamino)methyl)...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325895(CHEMBL1224667 | N-(3-((6-(4-fluoro-2-methoxyphenyl...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325882(CHEMBL1224373 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]CC55940 human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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