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Found 193 with Last Name = 'ruiz' and Initial = 'fx'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  1.20nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16241(2,3-dihydroxypropanal | D,L-glyceraldehyde | Glyce...)
Affinity DataIC50:  10nMAssay Description:Inhibition of glyceraldehyde reduction activity of human AKR1B1More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50103642(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of retinaldehyde reductase activity of human AKR1B10More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Affinity DataIC50:  17nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Affinity DataIC50:  21nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Affinity DataIC50:  22nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Affinity DataIC50:  23nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439244(CHEMBL2418829)
Affinity DataIC50:  24nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50:  30nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Affinity DataIC50:  30nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Affinity DataIC50:  33nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50520394(CHEMBL4442726)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  38nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439244(CHEMBL2418829)
Affinity DataIC50:  47nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439243(CHEMBL2418998)
Affinity DataIC50:  50nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50520395(CHEMBL4526117)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  60nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439241(CHEMBL2418999)
Affinity DataIC50:  70nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)
Affinity DataIC50:  80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50:  80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50:  80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439242(CHEMBL2418828)
Affinity DataIC50:  80nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439242(CHEMBL2418828)
Affinity DataIC50:  85nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50575722(CHEMBL4875952)
Affinity DataIC50:  92nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439243(CHEMBL2418998)
Affinity DataIC50:  100nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427903(CHEMBL2326087)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50575725(CHEMBL4858653)
Affinity DataIC50:  102nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50575723(CHEMBL4873054)
Affinity DataIC50:  113nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439241(CHEMBL2418999)
Affinity DataIC50:  120nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50501152(CHEMBL3929927)
Affinity DataIC50:  130nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  134nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427904(CHEMBL2326086)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50575724(CHEMBL4855106)
Affinity DataIC50:  143nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427911(CHEMBL2326095)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439240(CHEMBL2418993)
Affinity DataIC50:  180nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50520396(CHEMBL4520763)
Affinity DataIC50:  180nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  181nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427903(CHEMBL2326087)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439238(CHEMBL2418995)
Affinity DataIC50:  190nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439239(CHEMBL2418994)
Affinity DataIC50:  200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439237(CHEMBL2418996)
Affinity DataIC50:  200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50439236(CHEMBL2418997)
Affinity DataIC50:  210nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427909(CHEMBL2326097)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataIC50:  216nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
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