TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 1.20nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 10nMAssay Description:Inhibition of glyceraldehyde reduction activity of human AKR1B1More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 12nMAssay Description:Inhibition of retinaldehyde reductase activity of human AKR1B10More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 30nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 60nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 113nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into templateMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation in to cDNA chain incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Institutes for Pharmaceutical Discovery , LLC
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair