BindingDB PrimarySearch_ki

Found 192 with Last Name = 'rzymski' and Initial = 't'

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562615(CHEMBL4764756)

Ki: 5.5nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair

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3D Structure (crystal)

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562617(CHEMBL4752141)

Ki: 11nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair

PDB MMDB KEGG
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562617(CHEMBL4752141)

Ki: 14nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562615(CHEMBL4764756)

Ki: 14nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508562(CHEMBL4541928)

IC50: 2nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562617(CHEMBL4752141)

IC50: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508559(CHEMBL4592338)

IC50: 4nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562616(CHEMBL4787269)

IC50: 5nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562615(CHEMBL4764756)

IC50: 6nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

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3D Structure (crystal)

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562613(CHEMBL4785028)

IC50: 8nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508565(CHEMBL4439789)

IC50: 9nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562615(CHEMBL4764756)

IC50: 11nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508535(CHEMBL4465124)

IC50: 11nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508542(CHEMBL4449586)

IC50: 11nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562617(CHEMBL4752141)

IC50: 12nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562640(CHEMBL4743561)

IC50: 12nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508560(CHEMBL4471955)

IC50: 15nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

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3D Structure (crystal)

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508526(CHEMBL4542245)

IC50: 17nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508537(CHEMBL4461874)

IC50: 18nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562616(CHEMBL4787269)

IC50: 19nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562614(CHEMBL4757431)

IC50: 21nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508540(CHEMBL4470835)

IC50: 22nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508564(CHEMBL4553861)

IC50: 22nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508543(CHEMBL4518022)

IC50: 26nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508527(CHEMBL4437856)

IC50: 30nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562618(CHEMBL4755524)

IC50: 32nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562625(CHEMBL4746396)

IC50: 32nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508544(CHEMBL4538989)

IC50: 33nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508556(CHEMBL4465233)

IC50: 33nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508554(CHEMBL4459213)

IC50: 33nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508558(CHEMBL4438803)

IC50: 35nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508563(CHEMBL4576710)

IC50: 36nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562631(CHEMBL4795993)

IC50: 37nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562628(CHEMBL4749973)

IC50: 37nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508557(CHEMBL4539068)

IC50: 38nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562630(CHEMBL4791136)

IC50: 38nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508538(CHEMBL4472403)

IC50: 38nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562625(CHEMBL4746396)

IC50: 40nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562628(CHEMBL4749973)

IC50: 40nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508536(CHEMBL4442954)

IC50: 41nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562619(CHEMBL4750622)

IC50: 43nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562631(CHEMBL4795993)

IC50: 47nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508530(CHEMBL4458729)

IC50: 49nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562613(CHEMBL4785028)

IC50: 55nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562614(CHEMBL4757431)

IC50: 56nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562640(CHEMBL4743561)

IC50: 56nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508545(CHEMBL4591819)

IC50: 59nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508529(CHEMBL4452425)

IC50: 62nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL

PNG

BDBM50562627(CHEMBL4762761)

IC50: 62nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL

PNG

BDBM50508555(CHEMBL4578329)

IC50: 69nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Displayed 1 to 50 (of 192 total ) | Next | Last >>

Filter my 192 hits

Targets 12▿
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 80
- Potassium voltage-gated channel subfamily H member 2 34
- MAP kinase-interacting serine/threonine-protein kinase 2 30
- MAP kinase-interacting serine/threonine-protein kinase 1 30
- Receptor-type tyrosine-protein kinase FLT3 4
- Cytochrome P450 1A2 2
- Cytochrome P450 2C19 2
- Cytochrome P450 2D6 2
- Receptor-type tyrosine-protein kinase FLT3 [D835Y] 2
- Receptor-type tyrosine-protein kinase FLT3 [D835H] 2
- Cytochrome P450 2B6 2
- Cytochrome P450 3A4 2
Publications 3▿
- Bioorg Med Chem Lett 29: 646-653 (2019) 80
- Eur J Med Chem 213: (2021) 70
- US Patent US10174013 (2019) 42
Institutions 2▿
- Selvita 122
- Ryvu Therapeutics 70
Affinity: 2 to 1.0E+5 nM▿
- Ki 4
- IC50 180
- Kd 8
- Affinity ≤ nM
Xtal structures: 5
Docked structures: 0
Catalog Cmpds: 1