Found 55 with Last Name = 'saghatelian' and Initial = 'a' TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 54nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 65nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 80nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 85nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Mus musculus (Mouse))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Mus musculus (Mouse))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 100nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 150nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Tissue and cell proteomes (50 μL) were treated with either FP-rhodamine (1 μM) or WHP01 (2 μM) for 30 min at 37 °C. The reactions were...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 370nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Tissue and cell proteomes (50 μL) were treated with either FP-rhodamine (1 μM) or WHP01 (2 μM) for 30 min at 37 °C. The reactions were...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 500nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 570nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of wild type c-FynMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of wild type c-AblMore data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type c-FynMore data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetAndrogen-dependent TFPI-regulating protein(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataIC50: 1.30E+3nMAssay Description:Tissue and cell proteomes (50 μL) were treated with either FP-rhodamine (1 μM) or WHP01 (2 μM) for 30 min at 37 °C. The reactions were...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.50E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.50E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 2.10E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 3.20E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of wild type c-AblMore data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 5.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 5.60E+3nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 5.60E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 6.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 7.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetAndrogen-dependent TFPI-regulating protein(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataIC50: 8.50E+3nMAssay Description:Tissue and cell proteomes (50 μL) were treated with either FP-rhodamine (1 μM) or WHP01 (2 μM) for 30 min at 37 °C. The reactions were...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of wild type CDK2More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of wild type CDK2More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
President And Fellows Of Harvard College
US Patent
President And Fellows Of Harvard College
US Patent
Affinity DataIC50: >1.00E+5nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
