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Found 1983 with Last Name = 'savage' and Initial = 'j'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM85818(Fluorocarazolol,(R) | Fluorocarazolol,(S))
Affinity DataKi:  0.0790nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM85818(Fluorocarazolol,(R) | Fluorocarazolol,(S))
Affinity DataKi:  0.114nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM85818(Fluorocarazolol,(R) | Fluorocarazolol,(S))
Affinity DataKi:  0.138nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513934(CHEMBL4443587)
Affinity DataKi:  0.360nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM85093(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)
Affinity DataKi:  0.430nMAssay Description:In vitro binding affinity to human Dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM85818(Fluorocarazolol,(R) | Fluorocarazolol,(S))
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  0.450nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50330860(CHEMBL1201356 | METHYLERGONOVINE | Methylergometri...)
Affinity DataKi:  0.490nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513931(CHEMBL4444446)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataKi:  0.550nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097218(4-(10H-Anthracen-9-ylidene)-1-methyl-piperidine | ...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]-ketanserinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50027065((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)
Affinity DataKi:  0.800nMAssay Description:Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  0.800nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093055(CHEMBL443796 | {2-[5-Methoxy-1-(naphthalene-1-sulf...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093046(CHEMBL75734 | {2-[1-(2,5-Dimethoxy-benzenesulfonyl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099890(3-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-p...)
Affinity DataKi:  1.40nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093054(CHEMBL75010 | {2-[5-Methoxy-1-(naphthalene-2-sulfo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50031942((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of recombinant human OGA expressed in Escherichia coli assessed as inhibitory constant using 4-MUGlcNAc as substrate incubated for 20 mins...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2.30nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099893(3-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-py...)
Affinity DataKi:  2.30nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097224(1-Methyl-4-thioxanthen-9-ylidene-piperidine | 1-me...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099889(3-[4-(4-Vinyl-phenyl)-piperazin-1-ylmethyl]-1H-pyr...)
Affinity DataKi:  2.80nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM141965(US8927507, 16)
Affinity DataKi:  2.80nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50027065((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093053(CHEMBL72574 | {2-[1-(4-Chloro-benzenesulfonyl)-5-m...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50001915(1-(3-chlorophenyl)piperazine | CHEMBL478 | m-Chlor...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099887(3-[4-(2-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-py...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513947(CHEMBL4545886)
Affinity DataKi:  3.30nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  3.5nMAssay Description:Compound was evaluated for its binding affinity towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50075360(3-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-p...)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM85093(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)
Affinity DataKi:  3.70nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097216(1-Methyl-4-xanthen-9-ylidene-piperidine | CHEMBL15...)
Affinity DataKi:  4nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099892(3-[4-(4-Methylsulfanyl-phenyl)-piperazin-1-ylmethy...)
Affinity DataKi:  4.70nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  4.90nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50099888(3-[4-(4-Ethyl-phenyl)-piperazin-1-ylmethyl]-1H-pyr...)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataKi:  5nMAssay Description:Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50093048(CHEMBL72554 | {2-[7-Methoxy-1-(naphthalene-2-sulfo...)
Affinity DataKi:  5nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513960(CHEMBL4561925)
Affinity DataKi:  5.30nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513955(CHEMBL4483089)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50513957(CHEMBL4456515)
Affinity DataKi:  5.60nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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