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Found 46 with Last Name = 'schilling' and Initial = 'a'
TargetMyeloblastin(Homo sapiens (Human))
University Of Bergen

Curated by ChEMBL
LigandPNGBDBM50031630(CHEMBL3359765)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human PR3 using keto-D-DY-FRET as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187007(5-chloro-3-(3,4-dioxo-2-(phenylamino)cyclobut-1-en...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187004(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal His-tagged human FPPS (1 to 353 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187002(4-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187003(3-(3,4-dioxo-2-(pentan-3-ylamino)cyclobut-1-enylam...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50186997(3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylam...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187016(2-hydroxy-3-(2-(isopropylamino)-3,4-dioxocyclobut-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187015(3-(2-(cyclohexylamino)-3,4-dioxocyclobut-1-enylami...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187014(3-(2-(tert-butylamino)-3,4-dioxocyclobut-1-enylami...)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187010(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  22nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187011(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  34nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187001(3-(2-hydroxy-4-nitrophenylamino)-4-(phenylamino)cy...)
Affinity DataIC50:  36nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50186999(3-(2-(furan-2-ylmethylamino)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50:  41nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187017(CHEMBL380052 | methyl 3-(3,4-dioxo-2-(phenylamino)...)
Affinity DataIC50:  53nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50186998(3-(2-hydroxy-5-nitrophenylamino)-4-(phenylamino)cy...)
Affinity DataIC50:  56nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187019(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  65nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187009(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  74nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187012(CHEMBL436940 | N-benzyl-3-(3,4-dioxo-2-(phenylamin...)
Affinity DataIC50:  139nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187020(3-(3,4-dioxo-2-(tetrahydro-2H-pyran-4-ylamino)cycl...)
Affinity DataIC50:  171nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187006(3-(2-hydroxyphenylamino)-4-(phenylamino)cyclobut-3...)
Affinity DataIC50:  476nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Bergen

Curated by ChEMBL
LigandPNGBDBM50031630(CHEMBL3359765)
Affinity DataIC50:  530nMAssay Description:Inhibition of human PR3 using keto-D-DY-FRET as substrate after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509177(CHEMBL4515661)
Affinity DataIC50:  540nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187008((R)-3-(2-(2,3-dihydro-1H-inden-1-ylamino)-3,4-diox...)
Affinity DataIC50:  548nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187021(3-(3,4-dioxo-2-(phenethylamino)cyclobut-1-enylamin...)
Affinity DataIC50:  926nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187000(3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509180(CHEMBL4550027)
Affinity DataIC50:  1.00E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509178(CHEMBL4516343)
Affinity DataIC50:  1.10E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509183(CHEMBL4534214)
Affinity DataIC50:  1.20E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM36510(1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic a...)
Affinity DataIC50:  1.30E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509174(CHEMBL4467922)
Affinity DataIC50:  1.50E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Bergen

Curated by ChEMBL
LigandPNGBDBM50031630(CHEMBL3359765)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509179(CHEMBL4550499)
Affinity DataIC50:  2.80E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235478(CHEMBL4100337)
Affinity DataIC50:  2.80E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509176(CHEMBL4577736)
Affinity DataIC50:  3.00E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187013(4-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-...)
Affinity DataIC50:  3.10E+3nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509181(CHEMBL4448870)
Affinity DataIC50:  3.70E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50:  5.00E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187018(2-hydroxy-N,N-dimethyl-3-(2-(methyl(phenyl)amino)-...)
Affinity DataIC50:  7.20E+3nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235474(CHEMBL4090167)
Affinity DataIC50:  7.70E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509182(CHEMBL4467306)
Affinity DataIC50:  8.10E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187005(3-(4-nitrophenylamino)-4-(phenylamino)cyclobut-3-e...)
Affinity DataIC50:  8.60E+3nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50509175(CHEMBL4566427)
Affinity DataIC50: >1.00E+4nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Bergen

Curated by ChEMBL
LigandPNGBDBM50031631(CHEMBL3359767)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Bergen

Curated by ChEMBL
LigandPNGBDBM50171289(Benzenemethanesulfonyl fluoride | CHEMBL190503 | P...)
Affinity DataIC50:  1.92E+4nMAssay Description:Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50187022(3-((2-hydroxyphenyl)(methyl)amino)-4-(phenylamino)...)
Affinity DataIC50:  2.86E+4nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed