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Found 434 with Last Name = 'schmidt' and Initial = 'cj'
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  1.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(CHEMBL3217125 | N-((cis)-4-aminocyclohexyl)-N-(3-c...)
Affinity DataKi:  1.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309959((exo)-1-methyl-N-(octahydrocyclopenta[c]pyrrol-5-y...)
Affinity DataKi:  2nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309958((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi:  2.40nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309954((exo)-1-methyl-N-(2-methyloctahydrocyclopenta[c]py...)
Affinity DataKi:  2.5nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  2.60nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataKi:  2.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309962((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  2.90nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309969((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  3.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309970((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi:  3.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14768((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Affinity DataKi:  4nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309957((exo)-N-(3-isopropoxybenzyl)-1-methyl-N-(octahydro...)
Affinity DataKi:  4nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309968((exo)-N-(2-(2-fluoropropyl)octahydrocyclopenta[c]p...)
Affinity DataKi:  4.40nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309956((exo)-N-(3-(cyclopentyloxy)benzyl)-1-methyl-N-(oct...)
Affinity DataKi:  5.30nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309967((exo)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-N-(2...)
Affinity DataKi:  11nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14760((R)-6,7-Dimethoxy-4-[3-(naphthalen-2-yloxy)-pyrrol...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
LigandPNGBDBM14764((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14766((R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolid...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14763((R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  17nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
LigandPNGBDBM14762((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  18nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14765((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Affinity DataKi:  18nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  19nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343301(2-((4-(4-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14755(6,7-dimethoxy-4-[8-(4-methylpiperazin-1-yl)sulfony...)
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309964((endo)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-1-me...)
Affinity DataKi:  27nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14756((R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1...)
Affinity DataKi:  44nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14761((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Affinity DataKi:  48nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14748((R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  54nM ΔG°:  -41.1kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14745((R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14761((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Affinity DataKi:  56nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  61nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14753((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Affinity DataKi:  67nM ΔG°:  -40.5kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14752((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Affinity DataKi:  68nM ΔG°:  -40.5kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14757((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Affinity DataKi:  77nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  88nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343305(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14743((R)-4-[3-(2-Chloro-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14744((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14741((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14747((R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14740((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14741((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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