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Found 527 with Last Name = 'schoepp' and Initial = 'dd'
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50039183(CHEMBL72850 | {(S)-2-Benzyl-3-[4-(3-hydroxy-phenyl...)
Affinity DataKi:  0.770nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM85212(CAS_5311260 | LY341495 | NSC_5311260)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50039180(CHEMBL308501 | {2-Benzyl-3-[(3R,4R)-4-(3-hydroxy-p...)
Affinity DataKi:  0.890nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 4(Homo sapiens (Human))
Allelix Biopharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  2.29nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50039181(2-Benzyl-3-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimet...)
Affinity DataKi:  2.60nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound towards metabotropic glutamate receptor 3 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  3.70nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50453378(CHEMBL2114114)
Affinity DataKi:  4nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50039183(CHEMBL72850 | {(S)-2-Benzyl-3-[4-(3-hydroxy-phenyl...)
Affinity DataKi:  4.40nMAssay Description:Tested for binding affinity towards delta receptor in rat brain homogenates using [3H]-D-Ala2-D-Leu3-enkephalin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50453377(CHEMBL2115154)
Affinity DataKi:  5.5nMAssay Description:Tested for binding affinity towards mu receptor in presence of [3H]-NAL radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  6nMAssay Description:Tested for binding affinity towards kappa receptor in presence of [3H]-EKC radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 4(Homo sapiens (Human))
Allelix Biopharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi:  6.43nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  6.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, kainate 4(Homo sapiens (Human))
Allelix Biopharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252103((2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-MET...)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  14.1nMAssay Description:Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 2 subtypes expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  14.1nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  14.1nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 4(Homo sapiens (Human))
Allelix Biopharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50013055(2-aminopentanedioateglutamate | L-Glutamate | glut...)
Affinity DataKi:  18.3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataKi:  23nMAssay Description:Binding affinity of the compound towards metabotropic glutamate receptor 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50453377(CHEMBL2115154)
Affinity DataKi:  23nMAssay Description:Tested for binding affinity towards kappa receptor in presence of [3H]-EKC radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50039183(CHEMBL72850 | {(S)-2-Benzyl-3-[4-(3-hydroxy-phenyl...)
Affinity DataKi:  40nMAssay Description:Tested for binding affinity towards kappa receptor in presence of [3H]-EKC radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]glycine from glycine site on the NMDA receptor.More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  40.6nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50034503((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Affinity DataKi:  61nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  66nMAssay Description:Tested for binding affinity towards kappa receptor in presence of [3H]-EKC radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  67nMAssay Description:Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 2 subtypes expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  67nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  74.9nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  75nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  85nMAssay Description:Inhibition of [3H]LY-341,495 binding to recombinant human mGlu2 receptorsMore data for this Ligand-Target Pair
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50013055(2-aminopentanedioateglutamate | L-Glutamate | glut...)
Affinity DataKi:  90nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  93nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  93.3nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  126nMAssay Description:Inhibition of [3H]LY-341,495 binding to recombinant human mGlu3 receptorsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50167033((1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]he...)
Affinity DataKi:  146nMAssay Description:Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  170nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM22778(6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione | 6...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]glycine from glycine site on the NMDA receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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