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Found 1223 with Last Name = 'schweinitz' and Initial = 'a'
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211565((R)-N-[(S)-1-(2-aminomethyl-5-chloro-benzylcarbamo...)
Affinity DataKi:  0.0330nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211578((S)-1-[(R)-4-(1-oxy-pyridin-2-yl)-2-phenylmethanes...)
Affinity DataKi:  0.0490nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211567((R)-N-[(S)-1-(2-aminomethyl-5-chloro-benzylcarbamo...)
Affinity DataKi:  0.0590nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM104907(US8569313, Inhibitor 15)
Affinity DataKi:  0.0690nMAssay Description:Inhibition assay using matriptase enzymeMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM50253952(3-{(S)-3-[4-(2-Amino-ethyl)-piperidin-1-yl]-2-[3-(...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of matriptase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211585(CHEMBL389960 | [(R)-1-[(S)-2-(2-aminomethyl-5-chlo...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211571((R)-N-((S)-1-(2-(aminomethyl)-5-chlorobenzylamino)...)
Affinity DataKi:  0.0840nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211564((R)-N-[(5-chloro-2-ethyl-benzylcarbamoyl)-methyl]-...)
Affinity DataKi:  0.0950nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211563((S)-4-(2-aminomethyl-5-chloro-benzylcarbamoyl)-4-{...)
Affinity DataKi:  0.240nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211570(CHEMBL228984 | N-((S)-1-(2-(aminomethyl)-5-chlorob...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi:  0.25nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi:  0.300nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211582((R)-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-4...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211552((4-{[1-{[(2-aminomethyl-5-chloro-benzylcarbamoyl)-...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211572((4-{[1-{[(2-aminomethyl-5-chloro-benzylcarbamoyl)-...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108117(US8598206, Table 6, 2)
Affinity DataKi:  0.400nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM104930(US8569313, Inhibitor 47)
Affinity DataKi:  0.490nMAssay Description:Inhibition assay using matriptase enzymeMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211586((s)-4-(2-aminomethyl-5-chloro-benzylcarbamoyl)-4-[...)
Affinity DataKi:  0.520nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211578((S)-1-[(R)-4-(1-oxy-pyridin-2-yl)-2-phenylmethanes...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi:  0.600nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108106(US8598206, Table 6, 15)
Affinity DataKi:  0.600nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi:  0.600nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi:  0.600nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211587(CHEMBL427464 | N-[(R)-1-[(S)-2-(2-aminomethyl-5-ch...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108107(US8598206, Table 6, 16)
Affinity DataKi:  0.700nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM104931(US8569313, Inhibitor 48)
Affinity DataKi:  0.700nMAssay Description:Inhibition assay using matriptase enzymeMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM104908(CHEMBL468270 | US8569313, Inhibitor 16)
Affinity DataKi:  0.740nMAssay Description:Inhibition assay using matriptase enzymeMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211584(CHEMBL231393 | [1-{[(2-aminomethyl-5-chloro-benzyl...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108104(US8598206, Table 6, 13)
Affinity DataKi:  0.800nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108099(US8598206, Table 6, 8)
Affinity DataKi:  0.800nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211551(CHEMBL228285 | N-[1-[(S)-2-(2-aminomethyl-5-chloro...)
Affinity DataKi:  0.870nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108099(US8598206, Table 6, 8)
Affinity DataKi:  0.900nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211576(CHEMBL228341 | [(R)-1-[(S)-2-(2-aminomethyl-5-chlo...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211556(CHEMBL390402 | [(R)-1-[(S)-2-(2-aminomethyl-5-chlo...)
Affinity DataKi:  0.940nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM104908(CHEMBL468270 | US8569313, Inhibitor 16)
Affinity DataKi:  1nMAssay Description:Inhibition of matriptase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211577(CHEMBL229036 | [(R)-1-[(S)-2-(2-aminomethyl-5-chlo...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108105(US8598206, Table 6, 14)
Affinity DataKi:  1nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108108(US8598206, 117 | US8598206, 123)
Affinity DataKi:  1nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108108(US8598206, 117 | US8598206, 123)
Affinity DataKi:  1nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108115(US8598206, Table 6, 24)
Affinity DataKi:  1nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108102(US8598206, Table 6, 11)
Affinity DataKi:  1.20nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108102(US8598206, Table 6, 11)
Affinity DataKi:  1.30nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM47177(BDBM108100 | US8598206, Table 6, 9)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108115(US8598206, Table 6, 24)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Curacyte Discovery

Curated by ChEMBL
LigandPNGBDBM50211581(2-((R)-1-((S)-2-((2-(aminomethyl)-5-chlorobenzyl)c...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM47178(BDBM108103 | US8598206, Table 6, 12)
Affinity DataKi:  1.5nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM23921(3-amidinophenylalanine deriv., 63 | 3-amino-N-(3-{...)
Affinity DataKi:  1.5nMAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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