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Found 49 with Last Name = 'sedlock' and Initial = 'dm'
TargetProtein kinase C zeta type(Rattus norvegicus)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50478562(CHEMBL502491)
Affinity DataKi:  500nMAssay Description:Displacement of radiolabeled PDBU from PKC in rat forebrainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Rattus norvegicus)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50478561(CHEBI:69599 | Methylpendolmycin)
Affinity DataIC50:  35.2nMAssay Description:Displacement of radiolabeled PDBU from PKC in rat forebrainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101892(2-(7-Ethoxy-4-hydroxy-2,2-dioxo-2H-2lambda*6*,9-di...)
Affinity DataIC50:  40nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101903(CHEMBL50806 | N-(6-Ethoxy-benzothiazol-2-yl)-2-(6-...)
Affinity DataIC50:  170nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101892(2-(7-Ethoxy-4-hydroxy-2,2-dioxo-2H-2lambda*6*,9-di...)
Affinity DataIC50:  170nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128187((1R,3R)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxy...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292417((3S,5aR,10bR,11aS,3'S,5'R,11'R)-3,3'-Dibenzyl-2,3,...)
Affinity DataIC50:  230nMAssay Description:Inhibition of substance P receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128192((1S,3R)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128210((1R,3R)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-h...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101894(2-(4-Hydroxy-7-methoxy-2,2-dioxo-2H-2lambda*6*,9-d...)
Affinity DataIC50:  800nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101898(2-(4-Hydroxy-7-methanesulfonyl-2,2-dioxo-2H-2lambd...)
Affinity DataIC50:  1.10E+3nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101896(3-[2-(6-Ethoxycarbonyl-benzothiazol-2-ylsulfamoyl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128207((1S,3S)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128209((1R,3S)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128203((1R,3S)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxy...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128199((1S,3S)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarb...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119826(5-(6-Amino-purin-9-yl)-pentanoic acid hydroxyamide...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119832(4-(6-Amino-purin-9-yl)-N-hydroxy-butyramide | CHEM...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128188((1S,3R)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128206((1S,3S)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-h...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128191(2-[3-(6-Amino-purin-9-yl)-cyclopentyloxy]-N-hydrox...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292416(CHEMBL501675 | Ditryptophenaline)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of substance P receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128205(2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyloxy]-N-h...)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128204((1R,3R)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101890(2-(4-Hydroxy-2,2-dioxo-2H-2lambda*6*,9-dithia-1,4a...)
Affinity DataIC50:  2.10E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101893(2-(4-Hydroxy-7-methyl-2,2-dioxo-2H-2lambda*6*,9-di...)
Affinity DataIC50:  2.20E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128202((1R,3S)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-h...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128195((1R,3R)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-aceti...)
Affinity DataIC50:  2.88E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101900(2-(4-Hydroxy-7-nitro-2,2-dioxo-2H-2lambda*6*,9-dit...)
Affinity DataIC50:  3.50E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101895(2-(7-Chloro-4-hydroxy-2,2-dioxo-2H-2lambda*6*,9-di...)
Affinity DataIC50:  3.50E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119842(6-(6-Amino-purin-9-yl)-hexanoic acid hydroxyamide ...)
Affinity DataIC50:  3.54E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101897(2-(7-Fluoro-4-hydroxy-2,2-dioxo-2H-2lambda*6*,9-di...)
Affinity DataIC50:  3.70E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101899(2-(4-Hydroxy-2,2-dioxo-7-phenoxy-2H-2lambda*6*,9-d...)
Affinity DataIC50: >5.00E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101902(2-(4-Hydroxy-2,2-dioxo-7-phenyl-2H-2lambda*6*,9-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128197((1S,3R)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-h...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128201((1S,3R)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxy...)
Affinity DataIC50: >7.00E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128190((1S,3S)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-...)
Affinity DataIC50:  7.32E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101891(5-Methoxy-2,2-dioxo-2H-2lambda*6*,9-dithia-1,4a-di...)
Affinity DataIC50:  7.70E+4nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128186((1S,3S)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxy...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128189((1S,3S)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-aceti...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128194((1R,3R)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarb...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101901(2,2-Dioxo-7-trifluoromethoxy-2H-2lambda*6*,9-dithi...)
Affinity DataIC50: >1.20E+5nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101889(2-(7-Cyclohexyl-4-hydroxy-2,2-dioxo-2H-2lambda*6*,...)
Affinity DataIC50: >1.20E+5nMAssay Description:Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128211((1S,3R)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarb...)
Affinity DataIC50:  1.88E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128200((1S,3R)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-aceti...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128198((1R,3S)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-aceti...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128196((1R,3S)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128193((1R,3S)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarb...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50128208((1R,3R)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed