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Found 119 with Last Name = 'seebeck' and Initial = 't'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148238(CHEMBL3765037)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM86219(CAS_5537 | NSC_5537 | Trequinsin)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148240(CHEMBL3763271)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of full length human recombinant PDE4B2 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148195(CHEMBL3765188)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148194(CHEMBL3763456)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4D3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148237(CHEMBL3763233)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PDE4D3 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148239(CHEMBL3764370)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PDE4A1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148195(CHEMBL3765188)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397108(CHEMBL85005)
Affinity DataIC50:  4nMAssay Description:Inhibition of Trypanosoma brucei TbrPDEB1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human PDE4B1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM15297(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE4C1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148237(CHEMBL3763233)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148238(CHEMBL3765037)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148239(CHEMBL3764370)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  49nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  55nMAssay Description:Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP af...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148254(CHEMBL3765606)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148247(CHEMBL3765010)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148255(CHEMBL3765786)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148250(CHEMBL3765222)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148249(CHEMBL3763352)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148248(CHEMBL3765581)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148252(CHEMBL3764909)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148251(CHEMBL3765225)
Affinity DataIC50:  126nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Leishmania major)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  130nMAssay Description:Inhibition of Leishmania major recombinant PDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proxim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148253(CHEMBL3765733)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397079(CHEMBL2171451)
Affinity DataIC50:  160nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma cruzi)
University Of North Carolina

LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50:  230nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397082(CHEMBL2171460)
Affinity DataIC50:  250nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148240(CHEMBL3763271)
Affinity DataIC50:  316nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50148194(CHEMBL3763456)
Affinity DataIC50:  316nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397086(CHEMBL2171456)
Affinity DataIC50:  400nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397106(CHEMBL2171660)
Affinity DataIC50:  410nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397102(CHEMBL2171664)
Affinity DataIC50:  500nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50397081(CHEMBL2171461)
Affinity DataIC50:  500nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
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