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Found 68 with Last Name = 'shangary' and Initial = 's'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300114((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300115((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300116((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  1.70nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300118((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  2nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  3nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300117((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  7nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  11nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  12nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  12.6nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31198(spiro-oxindole, 4)
Affinity DataKi:  13nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300121((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13.1nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300120((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  15.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  17nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  18nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31197(CHEMBL211045 | Nutlin-3 | med.21724, Compound 186)
Affinity DataKi:  36nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31197(CHEMBL211045 | Nutlin-3 | med.21724, Compound 186)
Affinity DataKi:  36nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31199(spiro-oxindole, 5)
Affinity DataKi:  38nM ΔG°:  -42.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31204(spiro-oxindole, 10)
Affinity DataKi:  39nM ΔG°:  -42.0kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31201(spiro-oxindole, 7)
Affinity DataKi:  44nM ΔG°:  -41.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  86nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  86nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31206(NSC 66811)
Affinity DataKi:  120nM ΔG°:  -39.2kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  170nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31200(spiro-oxindole, 6)
Affinity DataKi:  170nM ΔG°:  -38.4kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  180nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  260nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  280nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  290nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  320nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214872(5,6,7-trihydroxy-8-isobutyl-2-methyl-3-phenyl-chro...)
Affinity DataKi:  340nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214872(5,6,7-trihydroxy-8-isobutyl-2-methyl-3-phenyl-chro...)
Affinity DataKi:  400nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  480nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214870(5,6,7-trihydroxy-8-isobutyl-2-methyl-4H-chromen-4-...)
Affinity DataKi:  730nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196036(CHEMBL217223 | N-(benzenesulfonyl-phenyl)-2,3,4-tr...)
Affinity DataKi:  930nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of FAM-Bim peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214870(5,6,7-trihydroxy-8-isobutyl-2-methyl-4H-chromen-4-...)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31203(spiro-oxindole, 9)
Affinity DataKi:  4.00E+3nM ΔG°:  -30.6kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196035(CHEMBL214965 | N-phenyl-2,3,4-trihydroxy-5-benzyl-...)
Affinity DataKi:  8.30E+3nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196033(2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide | ...)
Affinity DataKi:  2.41E+4nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196031(CHEMBL216213 | N-[(2-Tert-butyl-benzenesulfonyl)-p...)
Affinity DataKi:  2.50E+4nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196037(CHEMBL415129 | biotin-betaA-betaA-DMRPEIWIAQELRRIG...)
Affinity DataIC50:  11nMAssay Description:Binding affinity to human Bcl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300114((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300116((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50:  25.7nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataIC50:  28.3nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300115((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50:  32.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300118((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50:  32.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataIC50:  52nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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