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Found 400 with Last Name = 'shuttleworth' and Initial = 'sj'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  580nM ΔG°:  -35.6kJ/molepH: 7.5 T: 2°CAssay Description:Mammalian target of rapamycin (mTOR) was assayed by monitoring phosphorylation of GFP-4EBP using a homogeneous time-resolved fluorescence resonance e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310701(US10150763, Example A)
Affinity DataIC50:  1.76nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124206(US8748458, 14)
Affinity DataIC50:  2nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM25021(3-{6-[(dimethylamino)methyl]-4-(morpholin-4-yl)thi...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124207(US8748458, 15)
Affinity DataIC50:  3nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25022(3-(6-{[(2-methoxyethyl)(methyl)amino]methyl}-4-(mo...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  5nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  5nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25019(3-[6-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM387173(US9938290, F)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25024(3-(6-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  7nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  7nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25018(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124199(US8748458, 3)
Affinity DataIC50:  9nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  10nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25023(3-{6-[(4-methylpiperazin-1-yl)methyl]-4-(morpholin...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  10nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291361(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Affinity DataIC50:  10nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291361(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Affinity DataIC50:  10nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124205(US8748458, 11)
Affinity DataIC50:  13nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  15nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  15nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124200(US8748458, 4)
Affinity DataIC50:  16nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124202(US8748458, 8)
Affinity DataIC50:  19nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  19nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  19nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM25020(3-[7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291364(US9580442, Example L | US9938290, L | [2-(1H-Indol...)
Affinity DataIC50:  21nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291364(US9580442, Example L | US9938290, L | [2-(1H-Indol...)
Affinity DataIC50:  21nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM124201(US8748458, 5)
Affinity DataIC50:  22nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291366(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  22nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291366(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  22nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  25nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  25nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291362(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Affinity DataIC50:  26nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291362(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Affinity DataIC50:  26nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-B receptor(Homo sapiens (Human))
Tularik

Curated by ChEMBL
LigandPNGBDBM50147019(3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-methoxy-2,...)
Affinity DataIC50:  29nMAssay Description:Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Tularik

Curated by ChEMBL
LigandPNGBDBM50147019(3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-methoxy-2,...)
Affinity DataIC50:  29nMAssay Description:Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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