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Found 86 with Last Name = 'subashi' and Initial = 't'
LigandPNGBDBM50117662(CHEMBL3613706)
Affinity DataIC50:  6nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117663(CHEMBL3613707)
Affinity DataIC50:  6nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117663(CHEMBL3613707)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117662(CHEMBL3613706)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50:  12nMAssay Description:Inhibition of KHK (unknown origin) using D-fructose as substrate after 60 mins in presence of ATP by LC-MS analysisMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17051(BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophe...)
Affinity DataIC50:  60nMAssay Description:Inhibition of cGAS in human THP1 cells assessed as reduction in salmon sperm dsDNA-induced IFN-beta expression preincubated for 1 hr followed by dsDN...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117668(CHEMBL3613712)
Affinity DataIC50:  63nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117668(CHEMBL3613712)
Affinity DataIC50:  63nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117667(CHEMBL3613711)
Affinity DataIC50:  72nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117667(CHEMBL3613711)
Affinity DataIC50:  79nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  92nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  100nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  204nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  205nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins fol...More data for this Ligand-Target Pair
TargetKetohexokinase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins fol...More data for this Ligand-Target Pair
LigandPNGBDBM50117666(CHEMBL3613710)
Affinity DataIC50:  365nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  389nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK-A expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins...More data for this Ligand-Target Pair
LigandPNGBDBM50117668(CHEMBL3613712)
Affinity DataIC50:  389nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK-A expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins...More data for this Ligand-Target Pair
LigandPNGBDBM50117668(CHEMBL3613712)
Affinity DataIC50:  394nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117666(CHEMBL3613710)
Affinity DataIC50:  398nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK-C expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK-C expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50349755(CHEMBL1809182 | US8822447, 50 | US9771375, Example...)
Affinity DataIC50:  590nMAssay Description:Inhibition of KHK (unknown origin) using D-fructose as substrate after 60 mins in presence of ATP by LC-MS analysisMore data for this Ligand-Target Pair
LigandPNGBDBM50117664(CHEMBL3613708)
Affinity DataIC50:  597nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117659(CHEMBL3613703)
Affinity DataIC50:  631nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117664(CHEMBL3613708)
Affinity DataIC50:  631nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241195(CHEMBL4063606)
Affinity DataIC50:  640nMAssay Description:Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241195(CHEMBL4063606)
Affinity DataIC50:  646nMAssay Description:Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241195(CHEMBL4063606)
Affinity DataIC50:  670nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241195(CHEMBL4063606)
Affinity DataIC50:  676nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117659(CHEMBL3613703)
Affinity DataIC50:  682nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117667(CHEMBL3613711)
Affinity DataIC50:  760nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117667(CHEMBL3613711)
Affinity DataIC50:  794nMAssay Description:Inhibition of human MGAT3 expressed in HEK293 cells assessed as effect on incorporation of [1,3-14C] glycerol into TAG by TLC method in presence of D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241197(CHEMBL4072209)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241209(CHEMBL4101660)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241209(CHEMBL4101660)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
LigandPNGBDBM50117660(CHEMBL3613704)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117660(CHEMBL3613704)
Affinity DataIC50:  2.74E+3nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117661(CHEMBL3613705)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117661(CHEMBL3613705)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of MGAT3 (unknown origin) assessed effect on incorporation of [1-14C]decanoyl moiety into triacylglycerol using [1-14C]decanoyl-CoA and 1,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of MGAT1 (unknown origin) assessed as effect on incorporation of [1-14C]decanoyl moiety into DAG using [1-14C]decanoyl-CoA and 2-oleoylgly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117665(CHEMBL3613709)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of MGAT1 (unknown origin) assessed as effect on incorporation of [1-14C]decanoyl moiety into DAG using [1-14C]decanoyl-CoA and 2-oleoylgly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250106(CHEMBL4103560)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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