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Found 177 with Last Name = 'tachibana' and Initial = 'k'
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317664(2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-thi...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]mibolerone from human AR expressed in CHO-K1 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317655(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331872(5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317656(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by re...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331871(5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317660(3-[3-(4-Cyano-3-methylphenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317652(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317658(2-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331870(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317657(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]mibolerone from human AR expressed in CHO-K1 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317654(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  89nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220941(5-(4-(4-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,...)
Affinity DataIC50:  96nMAssay Description:Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331866(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331867(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331868(6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331869(6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197358(17b-hydroxy-7a-{9-(4,4,5,5,5-pentafluoropentylsulf...)
Affinity DataIC50:  110nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317659(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197366(CHEMBL225147 | N,N-dimethyl-7-(17b-hydroxy-5a-andr...)
Affinity DataIC50:  110nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197387(8-(17b-hydroxy-5a-androstan-3-one-7a-yl)-1-(piperi...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197376(CHEMBL224352 | N,N-diethyl-8-(17b-hydroxy-5a-andro...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220939(6-(3-(4-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by re...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317655(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220934(3-(4-(3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,...)
Affinity DataIC50:  170nMAssay Description:Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317656(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  170nMAssay Description:Displacement of [3H]mibolerone from human AR expressed in CHO-K1 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220937(8-((5S,7R,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317656(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197363(CHEMBL389277 | N,N-dimethyl-8-(17b-hydroxy-5a-andr...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]mibolerone from human AR expressed in CHO-K1 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317653(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197366(CHEMBL225147 | N,N-dimethyl-7-(17b-hydroxy-5a-andr...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220941(5-(4-(4-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,...)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197363(CHEMBL389277 | N,N-dimethyl-8-(17b-hydroxy-5a-andr...)
Affinity DataIC50:  260nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50220937(8-((5S,7R,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-...)
Affinity DataIC50:  260nMAssay Description:Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197381(8-(17b-hydroxy-5a-androstan-3-one-7a-yl)octanamide...)
Affinity DataIC50:  260nMAssay Description:Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317663(3-[3-(4-Cyano-2-methyl-3-trifluoromethylphenyl)-5,...)
Affinity DataIC50:  260nMAssay Description:Displacement of [3H]mibolerone from human AR expressed in CHO-K1 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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