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Found 72 with Last Name = 'takashima' and Initial = 't'
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220612(3-amino-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)m...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220606(CHEMBL249093 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220592(CHEMBL248875 | N-(3-phenethoxybenzyl)-4-hydroxyben...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220611(6-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220608(2-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220603(4-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220602(CHEMBL249307 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220595(3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(2-phenoxyeth...)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220591(CHEMBL249909 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220598(6-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220599(3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(phenoxymethy...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220610(CHEMBL250108 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220601(CHEMBL400917 | N-benzyl-3-{[(4-hydroxybenzoyl)amin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220597(CHEMBL398356 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220607(2-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220590(4-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220600(CHEMBL398357 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220594(3,5-dimethyl-N-(((1s,4s)-4-(phenoxymethyl)cyclohex...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220593(6-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220596(3-amino-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)me...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220605(6-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220609(3,5-dimethyl-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohe...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220604(CHEMBL249297 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Mus musculus)
Riken Center For Life Science Technologies

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  145nMAssay Description:Inhibition of mouse Mate1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 1(Mus musculus)
Riken Center For Life Science Technologies

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of mouse Oct1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220573(1-(1-(3-chloro-4-hydroxyphenyl)-1-hydroxypropan-2-...)
Affinity DataIC50:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220589(6-(1-hydroxy-2-(4-hydroxy-4-(3-(phenoxymethyl)phen...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220583(6-(2-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220586(1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...)
Affinity DataIC50:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220588(6-(1-hydroxy-2-(4-hydroxy-4-(3-methoxyphenyl)piper...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220581(7-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  8.70nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220574(6-(1-hydroxy-2-(4-hydroxy-4-p-tolylpiperidin-1-yl)...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220584(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220577(6-(2-(4-(3-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220576(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220582(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220578(6-(2-(4-(3,4-dihydro-1H-isochromen-7-yl)-4-hydroxy...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220580(4-(4-fluorophenyl)-1-(1-hydroxy-1-(4-hydroxy-2-met...)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220585(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220586(1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220586(1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220572(4-(4-fluorophenyl)-1-(1-hydroxy-1-(4-hydroxy-3-met...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220587(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  41nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220575(4-(4-fluoro-phenyl)-1-[2-hydroxy-2-(6-hydroxy-biph...)
Affinity DataIC50:  570nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220581(7-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220585(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220587(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220582(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  3.10E+3nMAssay Description:Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220574(6-(1-hydroxy-2-(4-hydroxy-4-p-tolylpiperidin-1-yl)...)
Affinity DataIC50:  3.30E+3nMAssay Description:Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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