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Found 586 with Last Name = 'talele' and Initial = 'tt'
TargetKappa-type opioid receptor(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50045776(CHEMBL982 | JF-1 | NALMEFENE | Nalmetrene | ORF-11...)
Affinity DataKi:  0.0830nMAssay Description:Displacement of [3H]U69,593 from human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50045776(CHEMBL982 | JF-1 | NALMEFENE | Nalmetrene | ORF-11...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Inhibition of FAM tagged p53-based peptide binding to recombinant human His-tagged MDM2 protein (residues 1 to 118 residues) incubated for 15 mins by...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254783(CHEMBL4092042)
Affinity DataKi:  2.5nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in mouse NIH/3T3 cells assessed as induction of IP3 formation after 0.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254782(CHEMBL4086240)
Affinity DataKi:  2.5nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in mouse NIH/3T3 cells assessed as induction of IP3 formation after 0.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14768((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Affinity DataKi:  4nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to 5-HT1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  6.40nMAssay Description:Displacement of N6-[3H]cyclohexyladenosine from adenosine receptor A1 in guinea pig forebrain membranes by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14766((R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolid...)
Affinity DataKi:  12nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14760((R)-6,7-Dimethoxy-4-[3-(naphthalen-2-yloxy)-pyrrol...)
Affinity DataKi:  12nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14764((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Affinity DataKi:  12nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50045776(CHEMBL982 | JF-1 | NALMEFENE | Nalmetrene | ORF-11...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cell membranes after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14763((R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  17nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14765((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Affinity DataKi:  18nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14762((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  18nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  19nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataKi:  20nMAssay Description:Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50004593(1,3-Dipropyl-8-(2,2,5,5-tetramethyl-cyclopentyl)-3...)
Affinity DataKi:  22nMAssay Description:Displacement of N6-[3H]cyclohexyladenosine from adenosine receptor A1 in guinea pig forebrain membranes by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254781(CHEMBL4083414)
Affinity DataKi:  30nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50005132(4,4-Dimethyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Affinity DataKi:  32nMAssay Description:Binding affinity to 5-HT1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254811(CHEMBL4091198)
Affinity DataKi:  40nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataKi:  40nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14756((R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1...)
Affinity DataKi:  44nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14761((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Affinity DataKi:  48nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254811(CHEMBL4091198)
Affinity DataKi:  50nMAssay Description:Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254781(CHEMBL4083414)
Affinity DataKi:  50nMAssay Description:Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254803(CHEMBL4101401)
Affinity DataKi:  50nMAssay Description:Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14748((R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  54nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14745((R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi:  56nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14761((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Affinity DataKi:  56nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  61nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14753((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Affinity DataKi:  67nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14752((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Affinity DataKi:  68nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14757((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Affinity DataKi:  77nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  88nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14751((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  94nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14747((R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6...)
Affinity DataKi:  100nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14741((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: >100nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14764((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Affinity DataKi:  104nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)
Affinity DataKi:  112nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14753((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Affinity DataKi:  121nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14757((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Affinity DataKi:  123nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  128nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14744((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi:  130nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14750((R)-4-[3-(Biphenyl-3-yloxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  136nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14752((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Affinity DataKi:  141nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  151nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14765((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Affinity DataKi:  152nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14748((R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Affinity DataKi:  161nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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