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Found 36 with Last Name = 'taylor' and Initial = 'jm'
TargetTyrosine-protein phosphatase non-receptor type 2 [V121L](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  24nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [V113L,M114V](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  29nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [G117E](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  32nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [V113I](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [M114V](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  45nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  87nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)
Affinity DataIC50:  95nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)
Affinity DataIC50:  109nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2 [V121L](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50:  138nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [L119V](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50:  142nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50:  163nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50:  1.60E+3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [L119V](Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50:  1.90E+3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 8(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50:  3.51E+6nMAssay Description:Inhibition of human OAT3 assessed as reduction in OAT3-mediated tenofovir transportMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50:  3.86E+6nMAssay Description:Inhibition of human OAT1 assessed as reduction in OAT1-mediated tenofovir transportMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP2B6 in human liver microsomes using bupropion as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP2D6 in human liver microsomes using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP3A5 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP3A5 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A5 in human liver microsomes using midazolam as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A5 in human liver microsomes using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | 2,2-Dimethyl-Butyric Acid |...)
Affinity DataIC50: >1.00E+7nMAssay Description:Direct inhibition of CYP2C9 in human liver microsomes using diclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed