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Found 1597 with Last Name = 'teleha' and Initial = 'c'
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nM ΔG°:  -61.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12659(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.0900nM ΔG°:  -56.8kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12661(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.100nM ΔG°:  -56.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12660(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12675(1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[...)
Affinity DataKi:  0.170nM ΔG°:  -55.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12676(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219966(CHEMBL23959)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18982(1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfa...)
Affinity DataKi:  0.330nM ΔG°:  -53.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12677(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Affinity DataKi:  0.370nM ΔG°:  -53.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219965(CHEMBL430913)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220479(CHEMBL23342)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12662(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.510nM ΔG°:  -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12666(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.520nM ΔG°:  -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219957(CHEMBL3085294)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12667(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220478(CHEMBL22622)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12663(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219962(CHEMBL431105)
Affinity DataKi:  0.700nMAssay Description:In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219969(CHEMBL23439)
Affinity DataKi:  0.700nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219954(CHEMBL283993)
Affinity DataKi:  0.700nMAssay Description:In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12671(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.730nM ΔG°:  -51.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219962(CHEMBL431105)
Affinity DataKi:  0.740nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220480(CHEMBL22433)
Affinity DataKi:  0.800nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.900nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12664(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.920nM ΔG°:  -51.1kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102630(11-Isobutyl-3-methyl-2,10-dioxo-1-oxa-3,9-diaza-cy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076995((6S,9R,10S)-10-Hydroxycarbamoyl-9-isobutyl-6-methy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219967(CHEMBL423475)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102610(10-Isobutyl-6,11-dioxo-6,7,9,10,11,12,13,14-octahy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219961(CHEMBL23483)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102604(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102630(11-Isobutyl-3-methyl-2,10-dioxo-1-oxa-3,9-diaza-cy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076993((2S,11S,12R)-12-Isobutyl-13-oxo-1,7diaza-cyclotrid...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102631(8-Isobutyl-9-oxo-6-oxa-1,10-diaza-tricyclo[11.6.1....)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076991((2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064340((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-[(R)-2-(4-met...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064340((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-[(R)-2-(4-met...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076995((6S,9R,10S)-10-Hydroxycarbamoyl-9-isobutyl-6-methy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102600(12-Isobutyl-4-methyl-3,11-dioxo-1-oxa-4,10-diaza-c...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076991((2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12673(1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220485(CHEMBL23354)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity to the CRF receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1/2(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50219963(CHEMBL276971)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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