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Found 57 with Last Name = 'terashima' and Initial = 's'
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Affinity DataKi:  10nMAssay Description:Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Affinity DataKi:  13nMAssay Description:The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Affinity DataKi:  63nMAssay Description:Binding affinity against the muscarinic M1 (cortex) subtype was evaluated using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50076089((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Affinity DataKi:  79nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403996(CHEMBL97765)
Affinity DataKi:  200nMAssay Description:Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403998(CHEMBL318849)
Affinity DataKi:  200nMAssay Description:Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403998(CHEMBL318849)
Affinity DataKi:  316nMAssay Description:Binding affinity against the muscarinic M1 (cortex) subtype was evaluated using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403996(CHEMBL97765)
Affinity DataKi:  316nMAssay Description:Binding affinity against the muscarinic M1 (cortex) subtype was evaluated using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404003(CHEMBL324725)
Affinity DataKi:  398nMAssay Description:The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404003(CHEMBL324725)
Affinity DataKi:  398nMAssay Description:The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404003(CHEMBL324725)
Affinity DataKi:  630nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404003(CHEMBL324725)
Affinity DataKi:  631nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404004(CHEMBL111224)
Affinity DataKi:  794nMAssay Description:The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404004(CHEMBL111224)
Affinity DataKi:  794nMAssay Description:The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403997(CHEMBL99618)
Affinity DataKi:  794nMAssay Description:Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404004(CHEMBL111224)
Affinity DataKi:  999nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403997(CHEMBL99618)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against the muscarinic M1 (cortex) subtype was evaluated using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404004(CHEMBL111224)
Affinity DataKi:  1.00E+3nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(CHEMBL1255901 | Huperzine A)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287625(1-Amino-13-eth-(E)-ylidene-11-trifluoromethyl-6-az...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301400(4-(3,4,5-tribromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287624(1-Amino-13-eth-(E)-ylidene-11-trifluoromethyl-6-az...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301402(4-(4-bromo-5-chloro-1H-pyrrol-2-yl)-1H-imidazo[4,5...)
Affinity DataIC50:  2.02E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301414(4-(3,5-dibromo-4-phenethyl-1H-pyrrol-2-yl)-1H-imid...)
Affinity DataIC50:  2.99E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287623(1-Amino-13-[2,2,2-trifluoro-eth-(E)-ylidene]-11-tr...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50173286(5-[3-[amino-(methylcarbamoylamino)methylidene]amin...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human acidic mammalian chitinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301409(4-(3,5-dibromo-4-methyl-1H-pyrrol-2-yl)-1H-imidazo...)
Affinity DataIC50:  5.02E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301401(4-(4,5-dichloro-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]p...)
Affinity DataIC50:  5.02E+3nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301413(4-(5-bromo-4-phenethyl-1H-pyrrol-2-yl)-1H-imidazo[...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215933(4-(4,5-dibromo-1H-pyrrol-2-yl)-N-methyl-1H-imidazo...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301410(4-(5-bromo-4-phenyl-1H-pyrrol-2-yl)-1H-imidazo[4,5...)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215931(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  4.36E+4nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215934(4-(4,5-dibromo-1H-pyrrol-2-yl)-1-methyl-1H-imidazo...)
Affinity DataIC50:  5.69E+4nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301407(4-(5-(biphenyl-4-yl)-4-bromo-1H-pyrrol-2-yl)-1H-im...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301406(4-(5-(biphenyl-3-yl)-4-bromo-1H-pyrrol-2-yl)-1H-im...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301405(4-(4-bromo-5-phenyl-1H-pyrrol-2-yl)-1H-imidazo[4,5...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215932(4-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)-1H-imidazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301404(4-(3,4-dibromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215929(4-(4,5-dibromo-1H-pyrrol-2-yl)-N,1-dimethyl-1H-imi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215930(4-(5-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215928(4-(4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301403(4-(4-bromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215927(4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215925(4-(4,5-dibromo-1H-pyrrol-2-yl)-N,N-dimethyl-1H-imi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215928(4-(4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215930(4-(5-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301420(4-(4,5-dibromo-3-phenethyl-1H-pyrrol-2-yl)-1H-imid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50301419(4-(3,5-dibromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human MMP12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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