Found 764 with Last Name = 'tesmer' and Initial = 'jj' TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Covalent inhibition of GRK5 (unknown origin) using porcine brain tubulin as substrate by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Covalent inhibition of GRK5 (unknown origin) using porcine brain tubulin as substrate by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Covalent inhibition of GRK5 (unknown origin) using porcine brain tubulin as substrate by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 11nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 17nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 20nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 21nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 21nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 23nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 23nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation countingMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 2(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of GRK3-mediated bovine tubulin phosphorylation by scintillation countingMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 50nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 50nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 57nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 57nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 60nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 61nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 69nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 69nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 70nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 78nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 80nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 84nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 97nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 97nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 110nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan
US Patent
The Regents Of The University Of Michigan
US Patent
Affinity DataIC50: 110nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
