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Found 67 with Last Name = 'thiel' and Initial = 'o'
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20579(N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...)
Affinity DataIC50:  1.80nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20581(N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  2nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20561(N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...)
Affinity DataIC50:  2.40nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20577(N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  2.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20577(N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  2.70nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20568(N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20583(N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...)
Affinity DataIC50:  3.10nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20581(N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  3.70nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20573(N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...)
Affinity DataIC50:  4.80nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20583(N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...)
Affinity DataIC50:  4.90nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20579(N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20582(N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20568(N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...)
Affinity DataIC50:  5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20573(N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...)
Affinity DataIC50:  6nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20582(N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20578(N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  7nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20570(N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50:  7.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20562(N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...)
Affinity DataIC50:  10nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20578(N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50:  16nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20563(N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...)
Affinity DataIC50:  19nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20580(N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...)
Affinity DataIC50:  20nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20574(N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20575(N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...)
Affinity DataIC50:  20nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20561(N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...)
Affinity DataIC50:  27nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20576(N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...)
Affinity DataIC50:  29nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20574(N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...)
Affinity DataIC50:  30nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20571(N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50:  39nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20580(N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...)
Affinity DataIC50:  39nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20570(N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50:  43nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20576(N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...)
Affinity DataIC50:  45nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50131840(CHEMBL3633142)
Affinity DataIC50:  50nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20571(N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50:  93nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20569(N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...)
Affinity DataIC50:  120nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20563(N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...)
Affinity DataIC50:  330nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50131839(CHEMBL3633141)
Affinity DataIC50:  348nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20562(N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20569(N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...)
Affinity DataIC50:  380nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50:  386nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50131842(CHEMBL3633151)
Affinity DataIC50:  521nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataIC50:  1.05E+3nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20566(N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20575(N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20567(N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20572(N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidi...)
Affinity DataIC50:  3.70E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20565(N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: >4.00E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20564(N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: >4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20565(N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: >4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20567(N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...)
Affinity DataIC50: >4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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