Compile Data Set for Download or QSAR
maximum 50k data
Found 3307 with Last Name = 'thornberry' and Initial = 'na'
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKi:  0.800nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282978(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  2.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282981(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  4.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116262((2S,5S)-5-[(S)-2-(2-Benzo[b]thiophen-3-yl-acetylam...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116264((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  8nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282984(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  11nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116255((2S,5S)-5-((S)-3-(S)-Methyl-2-phenylacetylamino-pe...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116256((S)-3-({1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-p...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116267((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  16nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataKi:  18nM ΔG°:  -44.2kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  19nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116264((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  26nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282979(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  27nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116268((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  38nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281182(3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...)
Affinity DataKi:  42nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282980(5-(Benzyl-phenethyl-amino)-3-{(S)-2-[(S)-3-methyl-...)
Affinity DataKi:  60nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  71nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116269((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  74nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116261((2S,5S)-5-((R)-3-Methyl-2-pyridin-2-yl-butyrylamin...)
Affinity DataKi:  75nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116259((S)-4-((3S,4S)-2-Acetylamino-3-methyl-pentanoylami...)
Affinity DataKi:  80nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116265((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  85nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284744(3-Allyloxycarbonylamino-5-[3-(1H-imidazol-2-yl)-na...)
Affinity DataKi:  90nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282983(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  100nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281184((S)-3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  100nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282977(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  113nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282982(5-Benzylcarbamoyloxy-3-{(S)-2-[(S)-3-methyl-2-(3-p...)
Affinity DataKi:  120nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116263((S)-3-{[(S)-(5S,7S)-6-((3S,4S)-2-Acetylamino-3-met...)
Affinity DataKi:  122nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116258((S)-3-{2-[3-((2S,3S)-2-Acetylamino-3-methyl-pentan...)
Affinity DataKi:  133nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116265((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  143nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116267((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  202nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116257(3-[((S)-{1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-...)
Affinity DataKi:  270nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284735(3-Allyloxycarbonylamino-5-(3-carbamoyl-naphthalen-...)
Affinity DataKi:  320nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  350nMAssay Description:Compound was tested for its inhibition against Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116270((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  360nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284734(3-Allyloxycarbonylamino-4-oxo-5-(3-phenylcarbamoyl...)
Affinity DataKi:  500nMAssay Description:Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116254(3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)-3-m...)
Affinity DataKi:  580nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281183((S)-3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  610nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284733(3-Allyloxycarbonylamino-5-(3-cyano-naphthalen-2-yl...)
Affinity DataKi:  620nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284740(3-Allyloxycarbonylamino-5-(3-hydroxymethyl-naphtha...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213208(CHEMBL3143890)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137257(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284745(3-Allyloxycarbonylamino-5-(4-carbamoyl-biphenyl-3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116266((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284741(3-(3-Allyloxycarbonylamino-4-carboxy-2-oxo-butoxy)...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284743(3-Allyloxycarbonylamino-4-oxo-5-phenoxy-pentanoic ...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137261(CHEMBL25211 | N-[4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50140533(CHEMBL25211 | N-[4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity of the compound towards human ERG potassium ion channel was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281181((S)-3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  3.10E+3nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
Displayed 1 to 50 (of 3307 total ) | Next | Last >>
Jump to: