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Found 1941 with Last Name = 'van duzer' and Initial = 'jh'
TargetHistone deacetylase 1(Homo sapiens (Human))
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM347485(US9790180, ID 019 | US9790180, ID 020)
Affinity DataIC50:  0.900nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139285(US8614223, 62 | US8614223, 66)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139312(US8614223, 90)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139258(US8614223, 34)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139338(US8614223, 124)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM347471(US9790180, ID 005)
Affinity DataIC50:  1.20nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213161(US9278963, 008)
Affinity DataIC50:  1.5nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213156(US9278963, 003)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213169(US9278963, 016)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213163(US9278963, 010)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213154(US9278963, 001)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM347468(US9790180, ID 004)
Affinity DataIC50:  2nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139264(US8614223, 40)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM110027(US8609678, N-(4-(7-(hydroxyamino)-7-oxoheptylcarba...)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM110118(US8609678, 2-(6,7-dimethoxy-3,4-dihydroisoquinolin...)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139260(US8614223, 36)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139259(US8614223, 35)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139257(US8614223, 33)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139256(US8614223, 32 | US8614223, 67)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139324(US8614223, 102)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139319(US8614223, 97)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139316(US8614223, 94)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139313(US8614223, 91)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213167(US9278963, 014)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213168(US9278963, 015)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50:  2nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213179(US9278963, 028)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139329(US8614223, 107)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139335(US8614223, 121)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139339(US8614223, 125)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139340(US8614223, 126)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139341(US8614223, 127)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139342(US8614223, 128)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM109968(US8609678, 4-((2,6-difluorophenyl)(methyl)amino)-N...)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139270(US8614223, 46)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139273(US8614223, 49)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139277(US8614223, 53)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139283(US8614223, 60)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139285(US8614223, 62 | US8614223, 66)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139256(US8614223, 32 | US8614223, 67)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139293(US8614223, 71)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139302(US8614223, 80)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139304(US8614223, 82)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM139309(US8614223, 87)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213162(US9278963, 009)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213165(US9278963, 012)
Affinity DataIC50:  2.20nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213170(US9278963, 017)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM249365(US9464073, 002 | US9884850, Compound 2)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM249365(US9464073, 002 | US9884850, Compound 2)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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