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Found 103 with Last Name = 'van houtvin' and Initial = 'n'
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214136(4-(((4-nitrophenethyl)(1-(2,6-difluorobenzoyl)pipe...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529561(CHEMBL4462175)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529578(CHEMBL4461693)
Affinity DataIC50:  10nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529577(CHEMBL4470211)
Affinity DataIC50:  10nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214142(4-(((4-nitrophenethyl)(1-picolinoylpiperidin-4-yl)...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214124(4-(((4-nitrophenethyl)(1-(2,4-dimethylnicotinoyl)p...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529585(CHEMBL4458006)
Affinity DataIC50:  13nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214121(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human CCR3 receptor assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214121(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529576(CHEMBL4531460)
Affinity DataIC50:  16nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214121(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214127(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  25nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214123(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423088(CHEMBL396031)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529575(CHEMBL4449462)
Affinity DataIC50:  38nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529574(CHEMBL4447751)
Affinity DataIC50:  40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529572(CHEMBL4583818)
Affinity DataIC50:  40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214140(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  40nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529571(CHEMBL4453736)
Affinity DataIC50:  40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423097(CHEMBL438129)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529570(CHEMBL4476127)
Affinity DataIC50:  50nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529573(CHEMBL4523002)
Affinity DataIC50:  50nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529580(CHEMBL4556206)
Affinity DataIC50:  60nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214130(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  63nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529560(CHEMBL4577912)
Affinity DataIC50:  63nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423077(CHEMBL232031)
Affinity DataIC50:  79nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214133(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  79nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529562(CHEMBL4587566)
Affinity DataIC50:  100nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214146(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214132(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214131(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214137(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423101(CHEMBL396030)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214141(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214129(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214134(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423098(CHEMBL233671)
Affinity DataIC50:  126nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423076(CHEMBL234101)
Affinity DataIC50:  158nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214145(4-(((1-(1-naphthoyl)piperidin-4-yl)(4-phenylbutyl)...)
Affinity DataIC50:  158nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214122(4-(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)...)
Affinity DataIC50:  158nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214143(4-({[2-(4-chloro-phenyl)-ethyl]-[1-(1-oxy-pyridine...)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214135(4-(((4-fluorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423067(CHEMBL234005)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423084(CHEMBL233675)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529565(CHEMBL4438313)
Affinity DataIC50:  220nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529569(CHEMBL4538981)
Affinity DataIC50:  250nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50214125(4-(((4-chlorophenethyl)(1-(2,6-difluorobenzoyl)pip...)
Affinity DataIC50:  250nMAssay Description:Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423074(CHEMBL234304)
Affinity DataIC50:  316nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50423085(CHEMBL390036 | CHEMBL535624 | CHEMBL535625)
Affinity DataIC50:  316nMAssay Description:Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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