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Found 75 with Last Name = 'vargas' and Initial = 'l'
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Affinity DataIC50:  23nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataIC50:  66nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Affinity DataIC50:  121nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20131(5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...)
Affinity DataIC50:  300nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005409(CHEBI:34682 | CHEMBL342169 | DIMPYLATE | Diazinon ...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataIC50:  5.00E+3nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20131(5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...)
Affinity DataIC50:  9.80E+3nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005196(CHEMBL3233990)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005195(CHEMBL1344483)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005200(CHEMBL3233993)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005197(CHEMBL3233991)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005216(CHEMBL1191355)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005199(CHEMBL3233992)
Affinity DataIC50:  6.14E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005194(CHEBI:5362 | CHEMBL1377579)
Affinity DataIC50:  9.30E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005217(CHEMBL1194868)
Affinity DataIC50:  2.75E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005219(CHEMBL3233995)
Affinity DataIC50:  3.21E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005408(CHEMBL141957 | CHEMBL3234001)
Affinity DataIC50:  3.40E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005402(CHEMBL3233999 | CHEMBL336258)
Affinity DataIC50:  3.50E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005407(CHEMBL3234000 | CHEMBL341550)
Affinity DataIC50:  3.58E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005348(CHEMBL3233998)
Affinity DataIC50:  3.63E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005198(CHEMBL3233022)
Affinity DataIC50:  3.79E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005218(CHEMBL3233994)
Affinity DataIC50:  3.81E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005296(CHEMBL1192998)
Affinity DataIC50:  3.89E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005336(CHEMBL3233997)
Affinity DataIC50:  3.94E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005297(CHEMBL1190535)
Affinity DataIC50:  4.06E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM46439((4-Hydroxy-3-methoxy-phenyl)-morpholin-4-yl-aceton...)
Affinity DataIC50:  4.09E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005404(CHEMBL140657 | CHEMBL1556015)
Affinity DataIC50:  4.48E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universidad Industrial De Santander

Curated by ChEMBL
LigandPNGBDBM50005299(CHEMBL3233996 | CHEMBL408953)
Affinity DataIC50:  4.78E+5nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Affinity DataEC50:  97nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20131(5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...)
Affinity DataEC50:  2.30E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataEC50:  1.60E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20133(2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...)
Affinity DataEC50:  1.40E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20134(2-(2,3-dimethoxyphenyl)-5-(4-methylphenyl)-3-[(2,4...)
Affinity DataEC50:  1.40E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20135(5-(4-chlorophenyl)-2-(2-methoxyphenyl)-3-[(2,4,6-t...)
Affinity DataEC50:  180nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20136(2-(4-fluoro-2-methoxyphenyl)-5-(4-fluorophenyl)-3-...)
Affinity DataEC50:  70nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20137(2-[2-(difluoromethoxy)phenyl]-5-(4-fluorophenyl)-3...)
Affinity DataEC50:  1.90E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20138(5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodio...)
Affinity DataEC50:  3.90E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20139(5-(4-fluorophenyl)-2-(2-methoxypyridin-3-yl)-3-[(2...)
Affinity DataEC50:  400nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20140(5-(4-chlorophenyl)-3-[(2,4-difluorophenyl)carbonyl...)
Affinity DataEC50:  6.70E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20141(5-(3,4-difluorophenyl)-2-(2,3-dimethoxyphenyl)-3-[...)
Affinity DataEC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20142(3-[(3,5-difluorophenyl)carbonyl]-2-(2,3-dimethoxyp...)
Affinity DataEC50:  2.10E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20143(2-(2,3-dimethoxyphenyl)-3-[(5-fluoro-2-methylpheny...)
Affinity DataEC50:  2.40E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20144(3-[(2,6-difluoro-4-methoxyphenyl)carbonyl]-2-(2,3-...)
Affinity DataEC50:  900nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20145(3-[(4-bromo-2,6-difluorophenyl)carbonyl]-2-(2,3-di...)
Affinity DataEC50:  900nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20146(2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...)
Affinity DataEC50:  700nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Affinity DataEC50:  27nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20131(5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...)
Affinity DataEC50:  300nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataEC50:  67nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20133(2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...)
Affinity DataEC50:  76nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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